Regulation of Plexin: A Ring of Structural Twists and Turns

Yi Chun Kuo, Xuewu Zhang

Research output: Contribution to journalShort survey

Abstract

The regulation of the guidance receptor plexin is incompletely understood. In this issue, Kong et al. (2016) present crystal structures of the full-length extracellular region of class A plexins, revealing its dual role in both autoinhibition and activation.

Original languageEnglish (US)
Pages (from-to)497-499
Number of pages3
JournalNeuron
Volume91
Issue number3
DOIs
StatePublished - Aug 3 2016

Keywords

  • activation
  • autoinhibition
  • axon guidance
  • dimerization
  • plexin
  • structure

ASJC Scopus subject areas

  • Neuroscience(all)

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