Regulation of postimplantation mouse embryonic growth by maternal vasoactive intestinal peptide

Catherine Y. Spong, Susan J. Lee, Susan K. McCune, Gretchen Gibney, Daniel T. Abebe, Douglas E. Brenneman, Joanna M. Hill

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Vasoactive intestinal peptide (VIP) is an identified regulator of growth in the embryonic day (E) 9-11 mouse. Mouse embryonic and extra-embryonic tissues were studied to identify the source of VIP at this critical time. VIP mRNA was detected in the decidua/trophoblast at E8 and declined until E10, after which it was not detectable. VIP mRNA was not apparent in the embryo until E11-E12. At E9, cells in decidua had VIP as well as lymphocyte marker (delta and CD3) immunoreactivity. VIP binding sites were dense in the decidua/trophoblast at E6, which gradually decreased until E10, VIP binding sites were detected in embryonic neuroepithelium by E9. The transient presence of VIP binding sites and mRNA in the decidua/trophoblast correlate with the identified period of VIP growth regulation, when VIP mRNA is absent in the embryo. Therefore, these findings suggest that maternal decidual lymphocytes are the source of VIP that regulate early postimplantation embryonic growth.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalAnnals of the New York Academy of Sciences
Volume897
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Vasoactive Intestinal Peptide
Mothers
Growth
Decidua
Trophoblasts
Messenger RNA
Lymphocytes
Binding Sites
Mouse
Embryonic Structures
Embryo
Tissue

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Regulation of postimplantation mouse embryonic growth by maternal vasoactive intestinal peptide. / Spong, Catherine Y.; Lee, Susan J.; McCune, Susan K.; Gibney, Gretchen; Abebe, Daniel T.; Brenneman, Douglas E.; Hill, Joanna M.

In: Annals of the New York Academy of Sciences, Vol. 897, 01.01.1999, p. 101-108.

Research output: Contribution to journalArticle

Spong, Catherine Y. ; Lee, Susan J. ; McCune, Susan K. ; Gibney, Gretchen ; Abebe, Daniel T. ; Brenneman, Douglas E. ; Hill, Joanna M. / Regulation of postimplantation mouse embryonic growth by maternal vasoactive intestinal peptide. In: Annals of the New York Academy of Sciences. 1999 ; Vol. 897. pp. 101-108.
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AU - Brenneman, Douglas E.

AU - Hill, Joanna M.

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