Regulation of signal transduction by endocytosis

Brian P. Ceresa; Sandra L. Schmid

doi:10.1016/S0955-0674(99)00077-0

Regulation of signal transduction by endocytosis

Brian P. Ceresa, Sandra L. Schmid

Research output: Contribution to journal › Review article › peer-review

263 Scopus citations

Abstract

Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the colocalization of activated receptors with downstream signaling molecules.

Original language	English (US)
Pages (from-to)	204-210
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/S0955-0674(99)00077-0
State	Published - Apr 1 2000

ASJC Scopus subject areas

Cell Biology

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10.1016/S0955-0674(99)00077-0

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title = "Regulation of signal transduction by endocytosis",

abstract = "Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the colocalization of activated receptors with downstream signaling molecules.",

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AB - Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the colocalization of activated receptors with downstream signaling molecules.

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JO - Current Opinion in Cell Biology

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Regulation of signal transduction by endocytosis

Abstract

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