Regulation of sister chromatid cohesion during the mitotic cell cycle

Ge Zheng, HongTao T. Yu

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Orderly execution of two critical events during the cell cycle––DNA replication and chromosome segregation––ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister chromatid cohesion. Timely establishment and dissolution of sister chromatid cohesion is a prerequisite for accurate chromosome segregation, and is tight regulated by the cell cycle machinery and cohesin-associated proteins. In this review, we discuss recent progress in the molecular understanding of sister chromatid cohesion during the mitotic cell cycle.

Original languageEnglish (US)
Pages (from-to)1089-1098
Number of pages10
JournalScience China Life Sciences
Volume58
Issue number11
DOIs
StatePublished - Nov 1 2015

Keywords

  • cell cycle
  • cohesin
  • cohesin loading
  • cohesin release
  • cohesion establishment
  • DNA replication
  • mitosis
  • sister chromatid cohesion

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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