Regulation of steroid secretion by adrenal tissue of a human anencephalic fetus

B. R. Carr, C. R. Parker, J. C. Porter, P. C. MacDonald, E. R. Simpson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

ACTH-stimulated adrenal tissue of a human anencephalic fetus, when maintained in organ culture, secreted appreciable quantities of cortisol but little dehydroisoandrosterone sulfate or pregnanolone sulfate. In the absence of ACTH, cortisol secretion was severly attenuated. Arginine vasopressin or αMSH, when added to the culture medium, did not stimulate steroid secretion. When whole human serum was present in the culture medium bathing the adrenal tissue of the anencephalic fetus, the rate of cortisol secretion was similar to that attained when lipoprotein-poor serum was in the medium. Based on these findings, it is concluded that in the presence of ACTH, the adrenals of the anenocephalic fetus secrete principally cortisol, and the failure of dehdroisoandrosterone sulfate and pregnenolone sulfate secretion is due to the absence of the fetal zone. The lack of stimulation of cortisol secretion by lipoprotein is probably due to a reduced number of low density lipoprotein receptors resulting from diminished ACTH stimulation before birth.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume50
Issue number5
StatePublished - 1980

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Hydrocortisone
Fetus
Adrenocorticotropic Hormone
Steroids
Tissue
Lipoproteins
Sulfates
Culture Media
Pregnanolone
Melanocyte-Stimulating Hormones
Dehydroepiandrosterone Sulfate
Arginine Vasopressin
LDL Receptors
Organ Culture Techniques
Serum
Parturition

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Carr, B. R., Parker, C. R., Porter, J. C., MacDonald, P. C., & Simpson, E. R. (1980). Regulation of steroid secretion by adrenal tissue of a human anencephalic fetus. Journal of Clinical Endocrinology and Metabolism, 50(5), 870-873.

Regulation of steroid secretion by adrenal tissue of a human anencephalic fetus. / Carr, B. R.; Parker, C. R.; Porter, J. C.; MacDonald, P. C.; Simpson, E. R.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 50, No. 5, 1980, p. 870-873.

Research output: Contribution to journalArticle

Carr, BR, Parker, CR, Porter, JC, MacDonald, PC & Simpson, ER 1980, 'Regulation of steroid secretion by adrenal tissue of a human anencephalic fetus', Journal of Clinical Endocrinology and Metabolism, vol. 50, no. 5, pp. 870-873.
Carr, B. R. ; Parker, C. R. ; Porter, J. C. ; MacDonald, P. C. ; Simpson, E. R. / Regulation of steroid secretion by adrenal tissue of a human anencephalic fetus. In: Journal of Clinical Endocrinology and Metabolism. 1980 ; Vol. 50, No. 5. pp. 870-873.
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