Regulation of superoxide dismutase synthesis in Candida albicans

Uma Gunasekaran, Ruipang Yang, Muthukumaran Gunasekaran

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The synthesis of superoxide dismutase [SOD: EC 1.15.1.1] in response to various cultural conditions was examined in Candida albicans, an opportunistic yeast which causes candidiasis in immunosuppressed patients. SOD plays an important role in protecting cells from the oxidative damage of superoxide radicals. Maximum SOD activity was found after 72 hrs of yeast growth. The optimum pH and temperature for the SOD activity were 7 and 40 °C, respectively. The major SOD activity was found in the cytosol fraction and the level of extracellular SOD was very low. The enzyme was stimulated to varying degrees by cholic acid, procaine and tocopherol. On the basis of inhibitor studies and other enzyme properties, the isolated enzyme from C. albicans is identified as copper and zinc superoxide dismutase.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalMycopathologia
Volume141
Issue number2
DOIs
StatePublished - Sep 14 1998

Keywords

  • (SOD)
  • Candida albicans
  • Superoxide dismutase
  • Yeast

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)

Fingerprint Dive into the research topics of 'Regulation of superoxide dismutase synthesis in Candida albicans'. Together they form a unique fingerprint.

  • Cite this