Regulation of superoxide dismutase synthesis in Candida albicans

Uma Gunasekaran, Ruipang Yang, Muthukumaran Gunasekaran

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The synthesis of superoxide dismutase [SOD: EC 1.15.1.1] in response to various cultural conditions was examined in Candida albicans, an opportunistic yeast which causes candidiasis in immunosuppressed patients. SOD plays an important role in protecting cells from the oxidative damage of superoxide radicals. Maximum SOD activity was found after 72 hrs of yeast growth. The optimum pH and temperature for the SOD activity were 7 and 40 °C, respectively. The major SOD activity was found in the cytosol fraction and the level of extracellular SOD was very low. The enzyme was stimulated to varying degrees by cholic acid, procaine and tocopherol. On the basis of inhibitor studies and other enzyme properties, the isolated enzyme from C. albicans is identified as copper and zinc superoxide dismutase.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalMycopathologia
Volume141
Issue number2
DOIs
StatePublished - 1998

Fingerprint

Candida albicans
Superoxide Dismutase
superoxide dismutase
synthesis
Enzymes
Yeasts
Cholic Acid
Procaine
Tocopherols
Candidiasis
Superoxides
Cytosol
Zinc
Copper
Temperature
Growth
enzymes
yeasts
cholic acid
procaine

Keywords

  • (SOD)
  • Candida albicans
  • Superoxide dismutase
  • Yeast

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Regulation of superoxide dismutase synthesis in Candida albicans. / Gunasekaran, Uma; Yang, Ruipang; Gunasekaran, Muthukumaran.

In: Mycopathologia, Vol. 141, No. 2, 1998, p. 59-63.

Research output: Contribution to journalArticle

Gunasekaran, Uma ; Yang, Ruipang ; Gunasekaran, Muthukumaran. / Regulation of superoxide dismutase synthesis in Candida albicans. In: Mycopathologia. 1998 ; Vol. 141, No. 2. pp. 59-63.
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