Acquisition of increased sensitivity to acetylcholine in various systems is associated with de-novo synthesis of acetylcholine receptors (AChR). But at what level is this biosynthesis controlled? The advent and application of recombinant technology has begun to clarify the molecular mechanisms involved. Each of the four receptor subunits are translated on a separate mRNA and require post-translational modification for 'ksconformational maturation'. Levels of AChR mRNA have been shown to increase as AChR levels rise, but it is not yet certain whether this is under transcriptional or post-transcriptional control. Another interesting possibility remains - AChR synthesis may be further controlled by regulation of subunit assembly.
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