Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

Yuntao S. Mao, Helen L. Yin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.

Original languageEnglish (US)
Pages (from-to)5-18
Number of pages14
JournalPflugers Archiv European Journal of Physiology
Volume455
Issue number1
DOIs
StatePublished - Oct 2007

Fingerprint

Actin Cytoskeleton
Actins
Protein Isoforms
Phosphatidylinositols
Lipids
1-phosphatidylinositol-4-phosphate 5-kinase

Keywords

  • Actin cytoskeleton
  • Arf6
  • Endocytosis
  • Phagocytosis
  • PIP5K
  • PIP

ASJC Scopus subject areas

  • Physiology

Cite this

Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. / Mao, Yuntao S.; Yin, Helen L.

In: Pflugers Archiv European Journal of Physiology, Vol. 455, No. 1, 10.2007, p. 5-18.

Research output: Contribution to journalArticle

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