Regulation of the mevalonate pathway

Research output: Contribution to journalArticle

4076 Citations (Scopus)

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalNature
Volume343
Issue number6257
StatePublished - Feb 1 1990

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Mevalonic Acid
LDL Receptors
Terpenes
Heart Diseases
Cholesterol
Enzymes
Growth
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Regulation of the mevalonate pathway. / Goldstein, Joseph L.; Brown, Michael S.

In: Nature, Vol. 343, No. 6257, 01.02.1990, p. 425-430.

Research output: Contribution to journalArticle

Goldstein, JL & Brown, MS 1990, 'Regulation of the mevalonate pathway', Nature, vol. 343, no. 6257, pp. 425-430.
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