Regulation of the mevalonate pathway

Research output: Contribution to journalReview article

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Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalNature
Volume343
Issue number6257
DOIs
StatePublished - Jan 1 1990

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