Regulation of the mevalonate pathway

Research output: Contribution to journalReview article

4207 Scopus citations

Abstract

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalNature
Volume343
Issue number6257
DOIs
StatePublished - Jan 1 1990

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