Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

Ana Tufegdžić Vidaković, Richard Mitter, Gavin P. Kelly, Michelle Neumann, Michelle Harreman, Marta Rodríguez-Martínez, Anna Herlihy, Juston C. Weems, Stefan Boeing, Vesela Encheva, Liam Gaul, Laura Milligan, David Tollervey, Ronald C. Conaway, Joan W. Conaway, Ambrosius P. Snijders, Aengus Stewart, Jesper Q. Svejstrup

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.

Original languageEnglish (US)
Pages (from-to)1245-1261.e21
JournalCell
Volume180
Issue number6
DOIs
StatePublished - Mar 19 2020
Externally publishedYes

Keywords

  • DNA damage
  • RNA polymerase II
  • transcription
  • ubiquitin
  • ubiquitylation
  • UV irradiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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