Regulation of Transmembrane Signaling by Phase Separation

Lindsay B. Case, Jonathon A. Ditlev, Michael K Rosen

Research output: Contribution to journalReview article

Abstract

Cell surface transmembrane receptors often form nanometer- to micrometer-scale clusters to initiate signal transduction in response to environmental cues. Extracellular ligand oligomerization, domain-domain interactions, and binding to multivalent proteins all contribute to cluster formation. Here we review the current understanding of mechanisms driving cluster formation in a series of representative receptor systems: glycosylated receptors, immune receptors, cell adhesion receptors, Wnt receptors, and receptor tyrosine kinases. We suggest that these clusters share properties of systems that undergo liquid-liquid phase separation and could be investigated in this light.

Original languageEnglish (US)
Pages (from-to)465-494
Number of pages30
JournalAnnual Review of Biophysics
Volume48
DOIs
StatePublished - May 6 2019

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Wnt Receptors
Receptor Protein-Tyrosine Kinases
Cell Surface Receptors
Cell Adhesion
Phase separation
Cues
Signal Transduction
Ligands
Signal transduction
Oligomerization
Cell adhesion
Liquids
Proteins
adhesion receptor

Keywords

  • biomolecular condensates
  • cell signaling
  • phase separation
  • receptor clusters
  • receptor organization

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Bioengineering
  • Biochemistry
  • Cell Biology

Cite this

Regulation of Transmembrane Signaling by Phase Separation. / Case, Lindsay B.; Ditlev, Jonathon A.; Rosen, Michael K.

In: Annual Review of Biophysics, Vol. 48, 06.05.2019, p. 465-494.

Research output: Contribution to journalReview article

Case, Lindsay B. ; Ditlev, Jonathon A. ; Rosen, Michael K. / Regulation of Transmembrane Signaling by Phase Separation. In: Annual Review of Biophysics. 2019 ; Vol. 48. pp. 465-494.
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