Abstract
Cell surface transmembrane receptors often form nanometer- to micrometer-scale clusters to initiate signal transduction in response to environmental cues. Extracellular ligand oligomerization, domain-domain interactions, and binding to multivalent proteins all contribute to cluster formation. Here we review the current understanding of mechanisms driving cluster formation in a series of representative receptor systems: glycosylated receptors, immune receptors, cell adhesion receptors, Wnt receptors, and receptor tyrosine kinases. We suggest that these clusters share properties of systems that undergo liquid-liquid phase separation and could be investigated in this light.
Original language | English (US) |
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Pages (from-to) | 465-494 |
Number of pages | 30 |
Journal | Annual Review of Biophysics |
Volume | 48 |
DOIs | |
State | Published - May 6 2019 |
Keywords
- biomolecular condensates
- cell signaling
- phase separation
- receptor clusters
- receptor organization
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Bioengineering
- Biochemistry
- Cell Biology