Regulatory T cells and the eye

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)

Abstract

Immune-mediated inflammation can be tolerated in many organs, however in the eye it has devastating consequences, as many of the tissues in the visual axis have limited or no capacity for regeneration. Multiple mechanisms and anatomical adaptations limit the expression of immune-mediated inflammation in the eye. Among these is the generation of regulatory T (Treg) cells, which act to prevent the induction and expression of T cell inflammation. At least four different pathways exist for the development of ocular Treg cells. The redundancy in the generation of Treg cells is a testament to their importance in restricting intraocular inflammation and preserving vision.

Original languageEnglish (US)
Title of host publicationChemical Immunology and Allergy
Pages131-139
Number of pages9
Volume92
DOIs
StatePublished - 2007

Publication series

NameChemical Immunology and Allergy
Volume92
ISSN (Print)16602242

Fingerprint

Regulatory T-Lymphocytes
Inflammation
Regeneration
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Niederkorn, J. Y. (2007). Regulatory T cells and the eye. In Chemical Immunology and Allergy (Vol. 92, pp. 131-139). (Chemical Immunology and Allergy; Vol. 92). https://doi.org/10.1159/000099263

Regulatory T cells and the eye. / Niederkorn, Jerry Y.

Chemical Immunology and Allergy. Vol. 92 2007. p. 131-139 (Chemical Immunology and Allergy; Vol. 92).

Research output: Chapter in Book/Report/Conference proceedingChapter

Niederkorn, JY 2007, Regulatory T cells and the eye. in Chemical Immunology and Allergy. vol. 92, Chemical Immunology and Allergy, vol. 92, pp. 131-139. https://doi.org/10.1159/000099263
Niederkorn JY. Regulatory T cells and the eye. In Chemical Immunology and Allergy. Vol. 92. 2007. p. 131-139. (Chemical Immunology and Allergy). https://doi.org/10.1159/000099263
Niederkorn, Jerry Y. / Regulatory T cells and the eye. Chemical Immunology and Allergy. Vol. 92 2007. pp. 131-139 (Chemical Immunology and Allergy).
@inbook{792b3649b86849c8b2775ce73057086d,
title = "Regulatory T cells and the eye",
abstract = "Immune-mediated inflammation can be tolerated in many organs, however in the eye it has devastating consequences, as many of the tissues in the visual axis have limited or no capacity for regeneration. Multiple mechanisms and anatomical adaptations limit the expression of immune-mediated inflammation in the eye. Among these is the generation of regulatory T (Treg) cells, which act to prevent the induction and expression of T cell inflammation. At least four different pathways exist for the development of ocular Treg cells. The redundancy in the generation of Treg cells is a testament to their importance in restricting intraocular inflammation and preserving vision.",
author = "Niederkorn, {Jerry Y.}",
year = "2007",
doi = "10.1159/000099263",
language = "English (US)",
isbn = "3805581874",
volume = "92",
series = "Chemical Immunology and Allergy",
pages = "131--139",
booktitle = "Chemical Immunology and Allergy",

}

TY - CHAP

T1 - Regulatory T cells and the eye

AU - Niederkorn, Jerry Y.

PY - 2007

Y1 - 2007

N2 - Immune-mediated inflammation can be tolerated in many organs, however in the eye it has devastating consequences, as many of the tissues in the visual axis have limited or no capacity for regeneration. Multiple mechanisms and anatomical adaptations limit the expression of immune-mediated inflammation in the eye. Among these is the generation of regulatory T (Treg) cells, which act to prevent the induction and expression of T cell inflammation. At least four different pathways exist for the development of ocular Treg cells. The redundancy in the generation of Treg cells is a testament to their importance in restricting intraocular inflammation and preserving vision.

AB - Immune-mediated inflammation can be tolerated in many organs, however in the eye it has devastating consequences, as many of the tissues in the visual axis have limited or no capacity for regeneration. Multiple mechanisms and anatomical adaptations limit the expression of immune-mediated inflammation in the eye. Among these is the generation of regulatory T (Treg) cells, which act to prevent the induction and expression of T cell inflammation. At least four different pathways exist for the development of ocular Treg cells. The redundancy in the generation of Treg cells is a testament to their importance in restricting intraocular inflammation and preserving vision.

UR - http://www.scopus.com/inward/record.url?scp=33947525524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947525524&partnerID=8YFLogxK

U2 - 10.1159/000099263

DO - 10.1159/000099263

M3 - Chapter

C2 - 17264489

AN - SCOPUS:33947525524

SN - 3805581874

SN - 9783805581875

VL - 92

T3 - Chemical Immunology and Allergy

SP - 131

EP - 139

BT - Chemical Immunology and Allergy

ER -