Regulatory T cells and the eye

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Immune-mediated inflammation can be tolerated in many organs, however in the eye it has devastating consequences, as many of the tissues in the visual axis have limited or no capacity for regeneration. Multiple mechanisms and anatomical adaptations limit the expression of immune-mediated inflammation in the eye. Among these is the generation of regulatory T (Treg) cells, which act to prevent the induction and expression of T cell inflammation. At least four different pathways exist for the development of ocular Treg cells. The redundancy in the generation of Treg cells is a testament to their importance in restricting intraocular inflammation and preserving vision.

Original languageEnglish (US)
Title of host publicationImmune Response and the Eye
EditorsJerry Niederkorn, Henry Kaplan
Pages131-139
Number of pages9
DOIs
StatePublished - Jul 30 2007

Publication series

NameChemical Immunology and Allergy
Volume92
ISSN (Print)1660-2242

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Niederkorn, J. Y. (2007). Regulatory T cells and the eye. In J. Niederkorn, & H. Kaplan (Eds.), Immune Response and the Eye (pp. 131-139). (Chemical Immunology and Allergy; Vol. 92). https://doi.org/10.1159/000099263