Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury

Malcolm P. MacConmara, Goro Tajima, Fionnuala O'Leary, Adam J. Delisle, Ann M. McKenna, Christopher G. Stallwood, John A. Mannick, James A. Lederer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Injury initiates local and systemic host responses and is known to increase CD4 Treg activity in mice and humans. This study uses a TCR transgenic T cell adoptive transfer approach and in vivo Treg depletion to determine specifically the in vivo influence of Tregs on antigen-driven CD4 T cell reactivity following burn injury in mice. We report here that injury in the absence of recipient and donor Tregs promotes high antigen-driven CD4 T cell expansion and increases the level of CD4 T cell reactivity. In contrast, CD4 T cell expansion and reactivity were suppressed significantly in injured Tregreplete mice. In additional experiments, we found that APCs prepared from burn- or sham-injured, Treg-depleted mice displayed significantly higher antigen-presenting activity than APCs prepared from normal mice, suggesting that Tregs may suppress injury responses by controlling the intensity of APC activity. Taken together, these findings demonstrate that Tregs can actively control the in vivo expansion and reactivity of antigen-stimulated, naïve CD4 T cells following severe injury.

Original languageEnglish (US)
Pages (from-to)137-147
Number of pages11
JournalJournal of Leukocyte Biology
Volume89
Issue number1
DOIs
StatePublished - Jan 2011

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CD4 Antigens
Regulatory T-Lymphocytes
T-Lymphocytes
Wounds and Injuries
Antigens
Adoptive Transfer
Burns

Keywords

  • CARS
  • Danger-associated molecular patterns (DAMPs)
  • Immunization
  • Inflammation
  • SIRS

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

MacConmara, M. P., Tajima, G., O'Leary, F., Delisle, A. J., McKenna, A. M., Stallwood, C. G., ... Lederer, J. A. (2011). Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. Journal of Leukocyte Biology, 89(1), 137-147. https://doi.org/10.1189/jlb.0210082

Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. / MacConmara, Malcolm P.; Tajima, Goro; O'Leary, Fionnuala; Delisle, Adam J.; McKenna, Ann M.; Stallwood, Christopher G.; Mannick, John A.; Lederer, James A.

In: Journal of Leukocyte Biology, Vol. 89, No. 1, 01.2011, p. 137-147.

Research output: Contribution to journalArticle

MacConmara, MP, Tajima, G, O'Leary, F, Delisle, AJ, McKenna, AM, Stallwood, CG, Mannick, JA & Lederer, JA 2011, 'Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury', Journal of Leukocyte Biology, vol. 89, no. 1, pp. 137-147. https://doi.org/10.1189/jlb.0210082
MacConmara, Malcolm P. ; Tajima, Goro ; O'Leary, Fionnuala ; Delisle, Adam J. ; McKenna, Ann M. ; Stallwood, Christopher G. ; Mannick, John A. ; Lederer, James A. / Regulatory T cells suppress antigen-driven CD4 T cell reactivity following injury. In: Journal of Leukocyte Biology. 2011 ; Vol. 89, No. 1. pp. 137-147.
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