Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis

A. Lowichik, J. C. Bernini, V. Tonk, M. Q. Ansari, N. K. Rollins, N. J. Winick, C. F. Timmons

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs of increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunophenotypic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalMedical and Pediatric Oncology
Volume26
Issue number2
DOIs
StatePublished - Feb 1 1996

Keywords

  • CT
  • MRI
  • acute lymphoblastic leukemia
  • central nervous system
  • mass lesion
  • relapse

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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