Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis

A. Lowichik, J. C. Bernini, V. Tonk, M. Q. Ansari, N. K. Rollins, N. J. Winick, C. F. Timmons

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs of increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunophenotypic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalMedical and Pediatric Oncology
Volume26
Issue number2
DOIs
StatePublished - Feb 1996

Fingerprint

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Central Nervous System
Bone Marrow Examination
Recurrence
Intracranial Pressure
Neuroimaging
Cytogenetics
Neoplasms
Leukemia
Drug Therapy

Keywords

  • acute lymphoblastic leukemia
  • central nervous system
  • CT
  • mass lesion
  • MRI
  • relapse

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis. / Lowichik, A.; Bernini, J. C.; Tonk, V.; Ansari, M. Q.; Rollins, N. K.; Winick, N. J.; Timmons, C. F.

In: Medical and Pediatric Oncology, Vol. 26, No. 2, 02.1996, p. 129-134.

Research output: Contribution to journalArticle

@article{67efda5fd2864d28889c85b8ba46b36e,
title = "Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis",
abstract = "Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs of increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunophenotypic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.",
keywords = "acute lymphoblastic leukemia, central nervous system, CT, mass lesion, MRI, relapse",
author = "A. Lowichik and Bernini, {J. C.} and V. Tonk and Ansari, {M. Q.} and Rollins, {N. K.} and Winick, {N. J.} and Timmons, {C. F.}",
year = "1996",
month = "2",
doi = "10.1002/(SICI)1096-911X(199602)26:2<129::AID-MPO11>3.0.CO;2-D",
language = "English (US)",
volume = "26",
pages = "129--134",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Relapse of precursor B-cell acute lymphoblastic leukemia as an isolated central nervous system mass lesion 9 years after initial diagnosis

AU - Lowichik, A.

AU - Bernini, J. C.

AU - Tonk, V.

AU - Ansari, M. Q.

AU - Rollins, N. K.

AU - Winick, N. J.

AU - Timmons, C. F.

PY - 1996/2

Y1 - 1996/2

N2 - Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs of increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunophenotypic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.

AB - Seven years after completion of chemotherapy for acute lymphoblastic leukemia, diagnosed at the age of 5 years, a black female presented with signs of increased intracranial pressure. Neuroimaging showed a large enhancing extra-axial occipital tumor mass. The resection specimen showed morphologic, cytogenetic, and immunophenotypic features consistent with relapse of the primary leukemia. Bone marrow examination was negative for malignancy. The long duration of complete remission followed by the formation of a mass in the central nervous system are highly unusual features of recurrent acute lymphoblastic leukemia.

KW - acute lymphoblastic leukemia

KW - central nervous system

KW - CT

KW - mass lesion

KW - MRI

KW - relapse

UR - http://www.scopus.com/inward/record.url?scp=0030032852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030032852&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1096-911X(199602)26:2<129::AID-MPO11>3.0.CO;2-D

DO - 10.1002/(SICI)1096-911X(199602)26:2<129::AID-MPO11>3.0.CO;2-D

M3 - Article

VL - 26

SP - 129

EP - 134

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 2

ER -