Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors

Michael A. Pulsipher, Brent R. Logan, Deidre M. Kiefer, Pintip Chitphakdithai, Marcie L. Riches, J. Douglas Rizzo, Paolo Anderlini, Susan F. Leitman, Hati Kobusingye, Raeanne M. Besser, John P. Miller, Rebecca J. Drexler, Aly Abdel-Mageed, Ibrahim A. Ahmed, Luke P. Akard, Andrew S. Artz, Edward D. Ball, Ruthee Lu Bayer, Carolyn Bigelow, Brian J. Bolwell & 41 others E. Randolph Broun, David C. Delgado, Katharine Duckworth, Christopher C. Dvorak, Theresa E. Hahn, Ann E. Haight, Parameswaran N. Hari, Brandon M. Hayes-Lattin, David A. Jacobsohn, Ann A. Jakubowski, Kimberly A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Michael Linenberger, Mark R. Litzow, Walter Longo, Margarida Magalhaes-Silverman, John M. McCarty, Joseph P. McGuirk, Shahram Mori, Vinod Parameswaran, Vinod K. Prasad, Scott D. Rowley, Witold B. Rybka, Indira Sahdev, Jeffrey R. Schriber, George B. Selby, Paul J. Shaughnessy, Shalini Shenoy, Thomas Spitzer, William T. Tse, Joseph P. Uberti, Madhuri Vusirikala, Edmund K. Waller, Daniel J. Weisdorf, Gregory A. Yanik, Willis H. Navarro, Mary M. Horowitz, Galen E. Switzer, Dennis L. Confer, Bronwen E. Shaw

Research output: Contribution to journalArticle

Abstract

Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42; P<0.001] and severe (OR 8.91; P<0.001) pain and toxicities (OR 1.84; P<0.001) with collection. Related stem cell donors were at increased risk of persistent toxicities (OR 1.56; P=0.021) and non-recovery from pain (OR 1.42; P=0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors reporting grade ≥2 pain had significant decreases in Health-Related Quality of Life (HR-QoL) scores at one month and one year post donation (P=0.004). In conclusion, related PBSC donors with comorbidities are at increased risk for pain, toxicity, and non-recovery at one year after donation. Risk profiles described in this study should be used for donor education, planning studies to improve the related donor experience, and decisions regarding donor deferral. Registered at clinicaltrials.gov identifier: 00948636.

Original languageEnglish (US)
Pages (from-to)844-854
Number of pages11
JournalHaematologica
Volume104
Issue number4
DOIs
StatePublished - Mar 31 2019

Fingerprint

Unrelated Donors
Tissue Donors
Odds Ratio
Pain
Comorbidity
Bone Marrow
Transplants
Peripheral Blood Stem Cells
Stem Cells
North America
Registries
Multivariate Analysis

ASJC Scopus subject areas

  • Hematology

Cite this

Pulsipher, M. A., Logan, B. R., Kiefer, D. M., Chitphakdithai, P., Riches, M. L., Rizzo, J. D., ... Shaw, B. E. (2019). Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors. Haematologica, 104(4), 844-854. https://doi.org/10.3324/haematol.2018.200121

Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors. / Pulsipher, Michael A.; Logan, Brent R.; Kiefer, Deidre M.; Chitphakdithai, Pintip; Riches, Marcie L.; Rizzo, J. Douglas; Anderlini, Paolo; Leitman, Susan F.; Kobusingye, Hati; Besser, Raeanne M.; Miller, John P.; Drexler, Rebecca J.; Abdel-Mageed, Aly; Ahmed, Ibrahim A.; Akard, Luke P.; Artz, Andrew S.; Ball, Edward D.; Bayer, Ruthee Lu; Bigelow, Carolyn; Bolwell, Brian J.; Broun, E. Randolph; Delgado, David C.; Duckworth, Katharine; Dvorak, Christopher C.; Hahn, Theresa E.; Haight, Ann E.; Hari, Parameswaran N.; Hayes-Lattin, Brandon M.; Jacobsohn, David A.; Jakubowski, Ann A.; Kasow, Kimberly A.; Lazarus, Hillard M.; Liesveld, Jane L.; Linenberger, Michael; Litzow, Mark R.; Longo, Walter; Magalhaes-Silverman, Margarida; McCarty, John M.; McGuirk, Joseph P.; Mori, Shahram; Parameswaran, Vinod; Prasad, Vinod K.; Rowley, Scott D.; Rybka, Witold B.; Sahdev, Indira; Schriber, Jeffrey R.; Selby, George B.; Shaughnessy, Paul J.; Shenoy, Shalini; Spitzer, Thomas; Tse, William T.; Uberti, Joseph P.; Vusirikala, Madhuri; Waller, Edmund K.; Weisdorf, Daniel J.; Yanik, Gregory A.; Navarro, Willis H.; Horowitz, Mary M.; Switzer, Galen E.; Confer, Dennis L.; Shaw, Bronwen E.

In: Haematologica, Vol. 104, No. 4, 31.03.2019, p. 844-854.

Research output: Contribution to journalArticle

Pulsipher, MA, Logan, BR, Kiefer, DM, Chitphakdithai, P, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Kobusingye, H, Besser, RM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Parameswaran, V, Prasad, VK, Rowley, SD, Rybka, WB, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Confer, DL & Shaw, BE 2019, 'Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors', Haematologica, vol. 104, no. 4, pp. 844-854. https://doi.org/10.3324/haematol.2018.200121
Pulsipher, Michael A. ; Logan, Brent R. ; Kiefer, Deidre M. ; Chitphakdithai, Pintip ; Riches, Marcie L. ; Rizzo, J. Douglas ; Anderlini, Paolo ; Leitman, Susan F. ; Kobusingye, Hati ; Besser, Raeanne M. ; Miller, John P. ; Drexler, Rebecca J. ; Abdel-Mageed, Aly ; Ahmed, Ibrahim A. ; Akard, Luke P. ; Artz, Andrew S. ; Ball, Edward D. ; Bayer, Ruthee Lu ; Bigelow, Carolyn ; Bolwell, Brian J. ; Broun, E. Randolph ; Delgado, David C. ; Duckworth, Katharine ; Dvorak, Christopher C. ; Hahn, Theresa E. ; Haight, Ann E. ; Hari, Parameswaran N. ; Hayes-Lattin, Brandon M. ; Jacobsohn, David A. ; Jakubowski, Ann A. ; Kasow, Kimberly A. ; Lazarus, Hillard M. ; Liesveld, Jane L. ; Linenberger, Michael ; Litzow, Mark R. ; Longo, Walter ; Magalhaes-Silverman, Margarida ; McCarty, John M. ; McGuirk, Joseph P. ; Mori, Shahram ; Parameswaran, Vinod ; Prasad, Vinod K. ; Rowley, Scott D. ; Rybka, Witold B. ; Sahdev, Indira ; Schriber, Jeffrey R. ; Selby, George B. ; Shaughnessy, Paul J. ; Shenoy, Shalini ; Spitzer, Thomas ; Tse, William T. ; Uberti, Joseph P. ; Vusirikala, Madhuri ; Waller, Edmund K. ; Weisdorf, Daniel J. ; Yanik, Gregory A. ; Navarro, Willis H. ; Horowitz, Mary M. ; Switzer, Galen E. ; Confer, Dennis L. ; Shaw, Bronwen E. / Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors. In: Haematologica. 2019 ; Vol. 104, No. 4. pp. 844-854.
@article{d1cc9666516d421cac692e90bb23b41d,
title = "Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors",
abstract = "Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42; P<0.001] and severe (OR 8.91; P<0.001) pain and toxicities (OR 1.84; P<0.001) with collection. Related stem cell donors were at increased risk of persistent toxicities (OR 1.56; P=0.021) and non-recovery from pain (OR 1.42; P=0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors reporting grade ≥2 pain had significant decreases in Health-Related Quality of Life (HR-QoL) scores at one month and one year post donation (P=0.004). In conclusion, related PBSC donors with comorbidities are at increased risk for pain, toxicity, and non-recovery at one year after donation. Risk profiles described in this study should be used for donor education, planning studies to improve the related donor experience, and decisions regarding donor deferral. Registered at clinicaltrials.gov identifier: 00948636.",
author = "Pulsipher, {Michael A.} and Logan, {Brent R.} and Kiefer, {Deidre M.} and Pintip Chitphakdithai and Riches, {Marcie L.} and Rizzo, {J. Douglas} and Paolo Anderlini and Leitman, {Susan F.} and Hati Kobusingye and Besser, {Raeanne M.} and Miller, {John P.} and Drexler, {Rebecca J.} and Aly Abdel-Mageed and Ahmed, {Ibrahim A.} and Akard, {Luke P.} and Artz, {Andrew S.} and Ball, {Edward D.} and Bayer, {Ruthee Lu} and Carolyn Bigelow and Bolwell, {Brian J.} and Broun, {E. Randolph} and Delgado, {David C.} and Katharine Duckworth and Dvorak, {Christopher C.} and Hahn, {Theresa E.} and Haight, {Ann E.} and Hari, {Parameswaran N.} and Hayes-Lattin, {Brandon M.} and Jacobsohn, {David A.} and Jakubowski, {Ann A.} and Kasow, {Kimberly A.} and Lazarus, {Hillard M.} and Liesveld, {Jane L.} and Michael Linenberger and Litzow, {Mark R.} and Walter Longo and Margarida Magalhaes-Silverman and McCarty, {John M.} and McGuirk, {Joseph P.} and Shahram Mori and Vinod Parameswaran and Prasad, {Vinod K.} and Rowley, {Scott D.} and Rybka, {Witold B.} and Indira Sahdev and Schriber, {Jeffrey R.} and Selby, {George B.} and Shaughnessy, {Paul J.} and Shalini Shenoy and Thomas Spitzer and Tse, {William T.} and Uberti, {Joseph P.} and Madhuri Vusirikala and Waller, {Edmund K.} and Weisdorf, {Daniel J.} and Yanik, {Gregory A.} and Navarro, {Willis H.} and Horowitz, {Mary M.} and Switzer, {Galen E.} and Confer, {Dennis L.} and Shaw, {Bronwen E.}",
year = "2019",
month = "3",
day = "31",
doi = "10.3324/haematol.2018.200121",
language = "English (US)",
volume = "104",
pages = "844--854",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "4",

}

TY - JOUR

T1 - Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors

AU - Pulsipher, Michael A.

AU - Logan, Brent R.

AU - Kiefer, Deidre M.

AU - Chitphakdithai, Pintip

AU - Riches, Marcie L.

AU - Rizzo, J. Douglas

AU - Anderlini, Paolo

AU - Leitman, Susan F.

AU - Kobusingye, Hati

AU - Besser, Raeanne M.

AU - Miller, John P.

AU - Drexler, Rebecca J.

AU - Abdel-Mageed, Aly

AU - Ahmed, Ibrahim A.

AU - Akard, Luke P.

AU - Artz, Andrew S.

AU - Ball, Edward D.

AU - Bayer, Ruthee Lu

AU - Bigelow, Carolyn

AU - Bolwell, Brian J.

AU - Broun, E. Randolph

AU - Delgado, David C.

AU - Duckworth, Katharine

AU - Dvorak, Christopher C.

AU - Hahn, Theresa E.

AU - Haight, Ann E.

AU - Hari, Parameswaran N.

AU - Hayes-Lattin, Brandon M.

AU - Jacobsohn, David A.

AU - Jakubowski, Ann A.

AU - Kasow, Kimberly A.

AU - Lazarus, Hillard M.

AU - Liesveld, Jane L.

AU - Linenberger, Michael

AU - Litzow, Mark R.

AU - Longo, Walter

AU - Magalhaes-Silverman, Margarida

AU - McCarty, John M.

AU - McGuirk, Joseph P.

AU - Mori, Shahram

AU - Parameswaran, Vinod

AU - Prasad, Vinod K.

AU - Rowley, Scott D.

AU - Rybka, Witold B.

AU - Sahdev, Indira

AU - Schriber, Jeffrey R.

AU - Selby, George B.

AU - Shaughnessy, Paul J.

AU - Shenoy, Shalini

AU - Spitzer, Thomas

AU - Tse, William T.

AU - Uberti, Joseph P.

AU - Vusirikala, Madhuri

AU - Waller, Edmund K.

AU - Weisdorf, Daniel J.

AU - Yanik, Gregory A.

AU - Navarro, Willis H.

AU - Horowitz, Mary M.

AU - Switzer, Galen E.

AU - Confer, Dennis L.

AU - Shaw, Bronwen E.

PY - 2019/3/31

Y1 - 2019/3/31

N2 - Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42; P<0.001] and severe (OR 8.91; P<0.001) pain and toxicities (OR 1.84; P<0.001) with collection. Related stem cell donors were at increased risk of persistent toxicities (OR 1.56; P=0.021) and non-recovery from pain (OR 1.42; P=0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors reporting grade ≥2 pain had significant decreases in Health-Related Quality of Life (HR-QoL) scores at one month and one year post donation (P=0.004). In conclusion, related PBSC donors with comorbidities are at increased risk for pain, toxicity, and non-recovery at one year after donation. Risk profiles described in this study should be used for donor education, planning studies to improve the related donor experience, and decisions regarding donor deferral. Registered at clinicaltrials.gov identifier: 00948636.

AB - Unlike unrelated donor registries, transplant centers lack uniform approaches to related donor assessment and deferral. To test whether related donors are at increased risk for donation-related toxicities, we conducted a prospective observational trial of 11,942 related and unrelated donors aged 18-60 years. Bone marrow (BM) was collected at 37 transplant and 78 National Marrow Donor Program centers, and peripheral blood stem cells (PBSC) were collected at 42 transplant and 87 unrelated donor centers in North America. Possible presence of medical comorbidities was verified prior to donation, and standardized pain and toxicity measures were assessed pre-donation, peri-donation, and one year following. Multivariate analyses showed similar experiences for BM collection in related and unrelated donors; however, related stem cell donors had increased risk of moderate [odds ratios (ORs) 1.42; P<0.001] and severe (OR 8.91; P<0.001) pain and toxicities (OR 1.84; P<0.001) with collection. Related stem cell donors were at increased risk of persistent toxicities (OR 1.56; P=0.021) and non-recovery from pain (OR 1.42; P=0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors with more significant comorbidities were at especially high risk for grade 2-4 pain (OR 3.43; P<0.001) and non-recovery from toxicities (OR 3.71; P<0.001) at one year. Related donors reporting grade ≥2 pain had significant decreases in Health-Related Quality of Life (HR-QoL) scores at one month and one year post donation (P=0.004). In conclusion, related PBSC donors with comorbidities are at increased risk for pain, toxicity, and non-recovery at one year after donation. Risk profiles described in this study should be used for donor education, planning studies to improve the related donor experience, and decisions regarding donor deferral. Registered at clinicaltrials.gov identifier: 00948636.

UR - http://www.scopus.com/inward/record.url?scp=85064008651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064008651&partnerID=8YFLogxK

U2 - 10.3324/haematol.2018.200121

DO - 10.3324/haematol.2018.200121

M3 - Article

VL - 104

SP - 844

EP - 854

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 4

ER -