Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the providing regional observations to study predictors of events in the coronary tree study)

Kyeong Ho Yun, Gary S. Mintz, Naim Farhat, Steven P. Marso, Nevio Taglieri, Stefan Verheye, Michael C. Foster, M. Pauliina Margolis, Barry Templin, Ke Xu, Ovidiu Dressler, Roxana Mehran, Gregg W. Stone, Akiko Maehara

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Previous angiographic studies have suggested that the future risk for major adverse cardiovascular events (MACEs) is related to coronary stenosis severity. The aim of this study was to use the grayscale and virtual histology (VH)-intravascular ultrasound (IVUS) data from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT) study to identify underlying lesion morphologic characteristics that might explain these findings. In PROSPECT, patients presenting with acute coronary syndromes in whom percutaneous coronary intervention was successful underwent 3-vessel grayscale and VH-IVUS and were followed for a median of 3.4 years for the incidence of MACEs. Overall, 3,115 nonculprit lesions detected by IVUS were divided into quartiles according to baseline angiographic diameter stenosis. From the first to fourth quartiles, there were increases in the prevalence of lesions with IVUS minimum luminal areas ≤4 mm2, IVUS plaque burden <70%, and VH-IVUS thin-cap fibroatheroma (13.4%, 22.0%, 24.2%, and 30.3%, respectively, p <0.001), along with an increased frequency of plaque ruptures and greater necrotic core volumes. The incidence of lesions with plaque burden <70%, minimum luminal area ≤4 mm2, and VH thin-cap fibroatheroma was highest in the fourth quartile (0%, 0.4%, 0.4%, and 2.8% in the first through fourth quartiles, respectively, p <0.001). Three-year MACE rates were also highest in the fourth quartile (0.3%, 0.7%, 1.3%, and 5.1%, respectively, p <0.001). In conclusion, increasing angiographic diameter stenosis was associated with an increased frequency of grayscale and VH-IVUS lesion morphologic features that have been associated with adverse events and that may, in part, explain why future MACEs were related to baseline lesion severity.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalAmerican Journal of Cardiology
Volume110
Issue number4
DOIs
StatePublished - Aug 15 2012

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Histology
Atherosclerotic Plaques
Pathologic Constriction
Coronary Stenosis
Incidence
Percutaneous Coronary Intervention
Acute Coronary Syndrome
Rupture

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the providing regional observations to study predictors of events in the coronary tree study). / Yun, Kyeong Ho; Mintz, Gary S.; Farhat, Naim; Marso, Steven P.; Taglieri, Nevio; Verheye, Stefan; Foster, Michael C.; Margolis, M. Pauliina; Templin, Barry; Xu, Ke; Dressler, Ovidiu; Mehran, Roxana; Stone, Gregg W.; Maehara, Akiko.

In: American Journal of Cardiology, Vol. 110, No. 4, 15.08.2012, p. 471-477.

Research output: Contribution to journalArticle

Yun, Kyeong Ho ; Mintz, Gary S. ; Farhat, Naim ; Marso, Steven P. ; Taglieri, Nevio ; Verheye, Stefan ; Foster, Michael C. ; Margolis, M. Pauliina ; Templin, Barry ; Xu, Ke ; Dressler, Ovidiu ; Mehran, Roxana ; Stone, Gregg W. ; Maehara, Akiko. / Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the providing regional observations to study predictors of events in the coronary tree study). In: American Journal of Cardiology. 2012 ; Vol. 110, No. 4. pp. 471-477.
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abstract = "Previous angiographic studies have suggested that the future risk for major adverse cardiovascular events (MACEs) is related to coronary stenosis severity. The aim of this study was to use the grayscale and virtual histology (VH)-intravascular ultrasound (IVUS) data from the Providing Regional Observations to Study Predictors of Events in the Coronary Tree (PROSPECT) study to identify underlying lesion morphologic characteristics that might explain these findings. In PROSPECT, patients presenting with acute coronary syndromes in whom percutaneous coronary intervention was successful underwent 3-vessel grayscale and VH-IVUS and were followed for a median of 3.4 years for the incidence of MACEs. Overall, 3,115 nonculprit lesions detected by IVUS were divided into quartiles according to baseline angiographic diameter stenosis. From the first to fourth quartiles, there were increases in the prevalence of lesions with IVUS minimum luminal areas ≤4 mm2, IVUS plaque burden <70{\%}, and VH-IVUS thin-cap fibroatheroma (13.4{\%}, 22.0{\%}, 24.2{\%}, and 30.3{\%}, respectively, p <0.001), along with an increased frequency of plaque ruptures and greater necrotic core volumes. The incidence of lesions with plaque burden <70{\%}, minimum luminal area ≤4 mm2, and VH thin-cap fibroatheroma was highest in the fourth quartile (0{\%}, 0.4{\%}, 0.4{\%}, and 2.8{\%} in the first through fourth quartiles, respectively, p <0.001). Three-year MACE rates were also highest in the fourth quartile (0.3{\%}, 0.7{\%}, 1.3{\%}, and 5.1{\%}, respectively, p <0.001). In conclusion, increasing angiographic diameter stenosis was associated with an increased frequency of grayscale and VH-IVUS lesion morphologic features that have been associated with adverse events and that may, in part, explain why future MACEs were related to baseline lesion severity.",
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T1 - Relation between angiographic lesion severity, vulnerable plaque morphology and future adverse cardiac events (from the providing regional observations to study predictors of events in the coronary tree study)

AU - Yun, Kyeong Ho

AU - Mintz, Gary S.

AU - Farhat, Naim

AU - Marso, Steven P.

AU - Taglieri, Nevio

AU - Verheye, Stefan

AU - Foster, Michael C.

AU - Margolis, M. Pauliina

AU - Templin, Barry

AU - Xu, Ke

AU - Dressler, Ovidiu

AU - Mehran, Roxana

AU - Stone, Gregg W.

AU - Maehara, Akiko

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