TY - JOUR
T1 - Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project)
AU - Wyszynski, Diego F.
AU - Waterworth, Dawn M.
AU - Barter, Philip J.
AU - Cohen, Jonathan C
AU - Kesäniemi, Y. Antero
AU - Mahley, Robert W.
AU - McPherson, Ruth
AU - Waeber, Gérard
AU - Bersot, Thomas P.
AU - Sharma, Sanjay S.
AU - Nolan, Vikki
AU - Middleton, Lefkos T.
AU - Sundseth, Scott S.
AU - Farrer, Lindsay A.
AU - Mooser, Vincent
AU - Grundy, Scott M
N1 - Funding Information:
This research project was funded by GlaxoSmithKline, Inc., Collegeville, Pennsylvania. Preventative cardiology
PY - 2005/1/15
Y1 - 2005/1/15
N2 - Genetic Epidemiology of Metabolic Syndrome is a multinational, family-based study to explore the genetic basis of the metabolic syndrome. Atherogenic dyslipidemia (defined as low plasma high-density lipoprotein cholesterol with elevated triglycerides (<25th and >75th percentile for age, gender, and country, respectively) identified affected subjects for the metabolic syndrome. This report examines the frequency at which atherogenic dyslipidemia predicts the metabolic syndrome of the National Cholesterol Education Program Adult Treatment Panel III (ATP-III). One thousand four hundred thirty-six (854 men/582 women) affected patients by our criteria were compared with 1,672 (737 men/935 women) unaffected persons. Affected patients had more hypertension, obesity, and hyperglycemia, and they met a higher number of ATP-III criteria (3.2 ± 1.1 SD vs 1.3 ± 1.1 SD, p <0.001). Overall, 76% of affected persons also qualified for the ATP-III definition (Cohen's κ 0.61, 95% confidence interval 0.59 to 0.64), similar to a separate group of 464 sporadic, unrelated cases (75%). Concordance increased from 41% to 82% and 88% for ages ≤35, 36 to 55, and <55 years, respectively. Affected status was also independently associated with waist circumference (p <0.001) and fasting glucose (p <0.001) but not systolic blood pressure (p = 0.43). Thus, the lipid-based criteria used to define affection status in this study substantially parallels the ATP-III definition of metabolic syndrome in subjects aged >35 years. In subjects aged <35 years, atherogenic dyslipidemia frequently occurs in the absence of other metabolic syndrome risk factors.
AB - Genetic Epidemiology of Metabolic Syndrome is a multinational, family-based study to explore the genetic basis of the metabolic syndrome. Atherogenic dyslipidemia (defined as low plasma high-density lipoprotein cholesterol with elevated triglycerides (<25th and >75th percentile for age, gender, and country, respectively) identified affected subjects for the metabolic syndrome. This report examines the frequency at which atherogenic dyslipidemia predicts the metabolic syndrome of the National Cholesterol Education Program Adult Treatment Panel III (ATP-III). One thousand four hundred thirty-six (854 men/582 women) affected patients by our criteria were compared with 1,672 (737 men/935 women) unaffected persons. Affected patients had more hypertension, obesity, and hyperglycemia, and they met a higher number of ATP-III criteria (3.2 ± 1.1 SD vs 1.3 ± 1.1 SD, p <0.001). Overall, 76% of affected persons also qualified for the ATP-III definition (Cohen's κ 0.61, 95% confidence interval 0.59 to 0.64), similar to a separate group of 464 sporadic, unrelated cases (75%). Concordance increased from 41% to 82% and 88% for ages ≤35, 36 to 55, and <55 years, respectively. Affected status was also independently associated with waist circumference (p <0.001) and fasting glucose (p <0.001) but not systolic blood pressure (p = 0.43). Thus, the lipid-based criteria used to define affection status in this study substantially parallels the ATP-III definition of metabolic syndrome in subjects aged >35 years. In subjects aged <35 years, atherogenic dyslipidemia frequently occurs in the absence of other metabolic syndrome risk factors.
UR - http://www.scopus.com/inward/record.url?scp=19944429029&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944429029&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2004.08.091
DO - 10.1016/j.amjcard.2004.08.091
M3 - Article
C2 - 15642551
AN - SCOPUS:19944429029
SN - 0002-9149
VL - 95
SP - 194
EP - 198
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 2
ER -