RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

GeorgeH Mccracken; MaryP Glode; LarrieD Sarff; SusanG Mize; MarkS Schiffer; JohnB Robbins; EmilC Gotschlich; Ida Orskov; Frits Orskov; Neonatal Meningitis Study Group Cooperative Neonatal Meningitis Study Group

doi:10.1016/S0140-6736(74)91413-5

RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

GeorgeH Mccracken, MaryP Glode, LarrieD Sarff, SusanG Mize, MarkS Schiffer, JohnB Robbins, EmilC Gotschlich, Ida Orskov, Frits Orskov, Neonatal Meningitis Study Group Cooperative Neonatal Meningitis Study Group

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.

Original language	English (US)
Pages (from-to)	246-250
Number of pages	5
Journal	The Lancet
Volume	304
Issue number	7875
DOIs	https://doi.org/10.1016/S0140-6736(74)91413-5
State	Published - Aug 3 1974

ASJC Scopus subject areas

General Medicine

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Mccracken, G., Glode, M., Sarff, L., Mize, S., Schiffer, M., Robbins, J., Gotschlich, E., Orskov, I., Orskov, F., & Cooperative Neonatal Meningitis Study Group, N. M. S. G. (1974). RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS. The Lancet, 304(7875), 246-250. https://doi.org/10.1016/S0140-6736(74)91413-5

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title = "RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS",

abstract = "The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.",

author = "GeorgeH Mccracken and MaryP Glode and LarrieD Sarff and SusanG Mize and MarkS Schiffer and JohnB Robbins and EmilC Gotschlich and Ida Orskov and Frits Orskov and {Cooperative Neonatal Meningitis Study Group}, {Neonatal Meningitis Study Group}",

note = "Funding Information: This study was supported by grants from the John A. Hart- Funding Information: We thank the following nurses for help in the follow-up of patients : Bonnie Tulumbus, Jocelyn Adelaar, Nancy Bennett, and Betty Hogan; Mr Waverly Howard, Ms Jean Nagle, Mr Dan Jass, Ms Pat Puma, Ms Bessie Clinkscale, and Ms Annie Mac Moffatt for technical assistance; Ms Gloria Block for the statistical analyses; and Dr K. Krawczynski for testing of sera for anti-HBc. We also thank the patients on the Surgical Service, New York University Hospital, who participated in this study. This work was supported by N.I.H. grant no. RR05688-06, an N.I.H. general research resource grant, N.H.L.I. contract no. HB-2236, and a grant-in-aid from the Hartford Foundation. A. M. P. is supported by a career scientist award from the Health Research Council of the City of New York (contract 1-533). Requests for reprints should New York Blood Center, 310 N.Y. 10021, U.S.A.",

year = "1974",

month = aug,

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doi = "10.1016/S0140-6736(74)91413-5",

language = "English (US)",

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pages = "246--250",

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T1 - RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

AU - Mccracken, GeorgeH

AU - Glode, MaryP

AU - Sarff, LarrieD

AU - Mize, SusanG

AU - Schiffer, MarkS

AU - Robbins, JohnB

AU - Gotschlich, EmilC

AU - Orskov, Ida

AU - Orskov, Frits

AU - Cooperative Neonatal Meningitis Study Group, Neonatal Meningitis Study Group

N1 - Funding Information: This study was supported by grants from the John A. Hart- Funding Information: We thank the following nurses for help in the follow-up of patients : Bonnie Tulumbus, Jocelyn Adelaar, Nancy Bennett, and Betty Hogan; Mr Waverly Howard, Ms Jean Nagle, Mr Dan Jass, Ms Pat Puma, Ms Bessie Clinkscale, and Ms Annie Mac Moffatt for technical assistance; Ms Gloria Block for the statistical analyses; and Dr K. Krawczynski for testing of sera for anti-HBc. We also thank the patients on the Surgical Service, New York University Hospital, who participated in this study. This work was supported by N.I.H. grant no. RR05688-06, an N.I.H. general research resource grant, N.H.L.I. contract no. HB-2236, and a grant-in-aid from the Hartford Foundation. A. M. P. is supported by a career scientist award from the Health Research Council of the City of New York (contract 1-533). Requests for reprints should New York Blood Center, 310 N.Y. 10021, U.S.A.

PY - 1974/8/3

Y1 - 1974/8/3

N2 - The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.

AB - The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.

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RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

Abstract

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