RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

GeorgeH Mccracken, MaryP Glode, LarrieD Sarff, SusanG Mize, MarkS Schiffer, JohnB Robbins, EmilC Gotschlich, Ida Orskov, Frits Orskov, Neonatal Meningitis Study Group Cooperative Neonatal Meningitis Study Group

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Abstract

The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.

Original languageEnglish (US)
Pages (from-to)246-250
Number of pages5
JournalThe Lancet
Volume304
Issue number7875
DOIs
Publication statusPublished - Aug 3 1974

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ASJC Scopus subject areas

  • Medicine(all)

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Mccracken, G., Glode, M., Sarff, L., Mize, S., Schiffer, M., Robbins, J., ... Cooperative Neonatal Meningitis Study Group, N. M. S. G. (1974). RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS. The Lancet, 304(7875), 246-250. https://doi.org/10.1016/S0140-6736(74)91413-5