RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

GeorgeH Mccracken; MaryP Glode; LarrieD Sarff; SusanG Mize; MarkS Schiffer; JohnB Robbins; EmilC Gotschlich; Ida Orskov; Frits Orskov; Neonatal Meningitis Study Group Cooperative Neonatal Meningitis Study Group

doi:10.1016/S0140-6736(74)91413-5

RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS

GeorgeH Mccracken, MaryP Glode, LarrieD Sarff, SusanG Mize, MarkS Schiffer, JohnB Robbins, EmilC Gotschlich, Ida Orskov, Frits Orskov, Neonatal Meningitis Study Group Cooperative Neonatal Meningitis Study Group

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.

Original language	English (US)
Pages (from-to)	246-250
Number of pages	5
Journal	The Lancet
Volume	304
Issue number	7875
DOIs	https://doi.org/10.1016/S0140-6736(74)91413-5
State	Published - Aug 3 1974

ASJC Scopus subject areas

Medicine(all)

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Mccracken, G., Glode, M., Sarff, L., Mize, S., Schiffer, M., Robbins, J., Gotschlich, E., Orskov, I., Orskov, F., & Cooperative Neonatal Meningitis Study Group, N. M. S. G. (1974). RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS. The Lancet, 304(7875), 246-250. https://doi.org/10.1016/S0140-6736(74)91413-5

RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS. / Mccracken, GeorgeH; Glode, MaryP; Sarff, LarrieD; Mize, SusanG; Schiffer, MarkS; Robbins, JohnB; Gotschlich, EmilC; Orskov, Ida; Orskov, Frits; Cooperative Neonatal Meningitis Study Group, Neonatal Meningitis Study Group.

In: The Lancet, Vol. 304, No. 7875, 03.08.1974, p. 246-250.

Research output: Contribution to journal › Article › peer-review

Mccracken, GeorgeH ; Glode, MaryP ; Sarff, LarrieD ; Mize, SusanG ; Schiffer, MarkS ; Robbins, JohnB ; Gotschlich, EmilC ; Orskov, Ida ; Orskov, Frits ; Cooperative Neonatal Meningitis Study Group, Neonatal Meningitis Study Group. / RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS. In: The Lancet. 1974 ; Vol. 304, No. 7875. pp. 246-250.

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title = "RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS",

abstract = "The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.",

author = "GeorgeH Mccracken and MaryP Glode and LarrieD Sarff and SusanG Mize and MarkS Schiffer and JohnB Robbins and EmilC Gotschlich and Ida Orskov and Frits Orskov and {Cooperative Neonatal Meningitis Study Group}, {Neonatal Meningitis Study Group}",

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AB - The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.

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