TY - JOUR
T1 - RELATION BETWEEN ESCHERICHIA COLI K1 CAPSULAR POLYSACCHARIDE ANTIGEN AND CLINICAL OUTCOME IN NEONATAL MENINGITIS
AU - Mccracken, GeorgeH
AU - Glode, MaryP
AU - Sarff, LarrieD
AU - Mize, SusanG
AU - Schiffer, MarkS
AU - Robbins, JohnB
AU - Gotschlich, EmilC
AU - Orskov, Ida
AU - Orskov, Frits
AU - Cooperative Neonatal Meningitis Study Group, Neonatal Meningitis Study Group
PY - 1974/8/3
Y1 - 1974/8/3
N2 - The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.
AB - The clinical outcome in fifty-seven infants with Escherichia coli meningitis was analysed with respect to the presence or absence of K1 capsular polysaccharide antigen. Mortality and morbidity in E. coli K1 meningitis were significantly greater than in meningitis caused by E. coli non-K1 strains. The amount of K1 antigen and length of time K1 antigen was present in serum and cerebrospinal fluid, as measured by countercurrent immuno-electrophoresis, were directly related to clinical outcome. E. coli K1 strains were more virulent in mice than non-K1 strains, and the lethal dose of K1 strains from infants who died was significantly lower than those values from infants who survived E. coli K1 meningitis.
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U2 - 10.1016/S0140-6736(74)91413-5
DO - 10.1016/S0140-6736(74)91413-5
M3 - Article
C2 - 4136144
AN - SCOPUS:0016255072
VL - 304
SP - 246
EP - 250
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 7875
ER -