Relation of Increased Hemoglobin A1c Levels to Severity of Peripheral Arterial Disease in Patients With Diabetes Mellitus

Wilbert S. Aronow, Chul Ahn, Melvin B. Weiss, Sateesh Babu

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The association between hemoglobin A1c levels and the severity of peripheral arterial disease (PAD) was investigated in 224 patients with diabetes mellitus and PAD. The mean hemoglobin A1c levels were 9.1 ± 2.1% in patients with diabetes with ankle-brachial indexes (ABIs) <0.60 and 7.1 ± 0.9% in those with ABIs of 0.60 to 0.89 (p <0.0001). Hemoglobin A1c levels <6.5% were present in 2 of 89 patients with diabetes (2%) with ABIs <0.60 and in 24 of 135 (18%) with ABIs of 0.60 to 0.89 (p = 0.0004). Hemoglobin A1c levels <7.0% were present in 24 of 89 patients with diabetes (27%) with ABIs <0.60 and in 63 of 135 (47%) with ABIs of 0.60 to 0.89 (p = 0.003). Hemoglobin A1c levels <7.5% were present in 30 of 89 patients with diabetes (34%) with ABIs <0.60 and in 92 of 135 (68%) with ABIs of 0.60 to 0.89 (p <0.0001). In conclusion, the higher the hemoglobin A1c levels in patients with diabetes with PAD, the higher the prevalence of severe PAD.

Original languageEnglish (US)
Pages (from-to)1468-1469
Number of pages2
JournalAmerican Journal of Cardiology
Volume99
Issue number10
DOIs
StatePublished - May 15 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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