TY - JOUR
T1 - Relation of Multiple Inflammatory Biomarkers to Incident Atrial Fibrillation
AU - Schnabel, Renate B.
AU - Larson, Martin G.
AU - Yamamoto, Jennifer F.
AU - Kathiresan, Sekar
AU - Rong, Jian
AU - Levy, Daniel
AU - Keaney, John F.
AU - Wang, Thomas J.
AU - Vasan, Ramachandran S.
AU - Benjamin, Emelia J.
N1 - Funding Information:
This study was supported by National Institutes of Health/National Heart, Lung, Blood Institute Grants N01-HC-25195 and 6R01-NS 17950, and National Institutes of Health Grants HL064753. HL076784, and AG028321 (E. J. Benjamin), 1 RO1HL71039 (R. S. Vasan), Bethesda, Maryland; National Institutes of Health Research Career Award K24 HL04334 (R. S. Vasan), Bethesda, Maryland; Deutsche Forschungsgemeinschaft (German Research Foundation) Research Fellowship SCHN 1149/1-1 (R. B. Schnabel), Bonn, Germany; and Grant 1K23HL083102, Doris Duke Charitable Foundation Clinical Scientist Development Award (S. Kathiresan), New York, New York.
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Basic and clinical studies have suggested that inflammation predisposes to atrial fibrillation (AF). We assessed the association of 12 circulating inflammatory biomarkers (i.e., C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, osteoprotegerin, P-selectin, and tumor necrosis factor receptor II) with incident AF in 2863 Framingham Offspring Study participants (mean age 60.7 years, SD = 9.4, 55% women). During follow-up (median 6 years), 148 participants (43% women) developed incident AF. In the multivariable proportional hazards models, the inflammatory biomarker panel was associated with incident AF (p = 0.03). With stepwise selection (p <0.01 for entry and retention), log-transformed osteoprotegerin was associated with incident AF (hazard ratio per SD 1.30, 95% confidence interval 1.08 to 1.56, p = 0.006). Adjusting for interim myocardial infarction or heart failure attenuated the association between osteoprotegerin and incident AF (hazard ratio 1.18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events.
AB - Basic and clinical studies have suggested that inflammation predisposes to atrial fibrillation (AF). We assessed the association of 12 circulating inflammatory biomarkers (i.e., C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, osteoprotegerin, P-selectin, and tumor necrosis factor receptor II) with incident AF in 2863 Framingham Offspring Study participants (mean age 60.7 years, SD = 9.4, 55% women). During follow-up (median 6 years), 148 participants (43% women) developed incident AF. In the multivariable proportional hazards models, the inflammatory biomarker panel was associated with incident AF (p = 0.03). With stepwise selection (p <0.01 for entry and retention), log-transformed osteoprotegerin was associated with incident AF (hazard ratio per SD 1.30, 95% confidence interval 1.08 to 1.56, p = 0.006). Adjusting for interim myocardial infarction or heart failure attenuated the association between osteoprotegerin and incident AF (hazard ratio 1.18, 95% confidence interval 0.98 to 1.43, p = 0.09). In conclusion, circulating osteoprotegerin concentration was significantly associated with incident AF in our community-based sample, possibly mediated by interim cardiovascular events.
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U2 - 10.1016/j.amjcard.2009.02.053
DO - 10.1016/j.amjcard.2009.02.053
M3 - Article
C2 - 19576326
AN - SCOPUS:67649304457
SN - 0002-9149
VL - 104
SP - 92
EP - 96
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 1
ER -