Relation of Troponin Elevation to Outcome in Patients With Infective Endocarditis

Jonathan B. Purcell, Mahesh Patel, Amit Khera, James A de Lemos, Lisa Forbess, Sharon Baker, Christopher H. Cabell, Gail E Peterson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Elevated troponin is increasingly recognized as a marker of cardiac injury and poor outcomes in diverse disease states. It was hypothesized that patients with infective endocarditis (IE) and elevated cardiac troponin would have more extensive IE and worse clinical outcomes. Patients were enrolled as part of the International Collaboration on Endocarditis (ICE) prospective cohort study; analysis of these patients was done retrospectively. Data from 83 consecutively enrolled patients from a single center were evaluated. Cardiac troponin I (cTnI) was drawn for clinical indications and before any cardiac surgery in 51 of the 83 patients. Outcomes evaluated were hospital mortality, annular or myocardial abscess on the basis of echocardiography or surgery, and central nervous system events. Of 51 patients with cTnI drawn, 33 (65%) had elevated cTnI ≥0.1 mg/dl. There were no differences in age, gender, prosthetic valve IE, Staphylococcus aureus IE, or history of coronary artery disease, congestive heart failure, or diabetes mellitus between patients with and without cTnI elevations. Patients with elevated cTnI were less likely to have isolated right-sided IE and more likely to have left ventricular systolic dysfunction or renal dysfunction (p <0.05 for each). In conclusion, elevated cTnI was associated with the composite of death, abscess, and central nervous system events (p <0.001).

Original languageEnglish (US)
Pages (from-to)1479-1481
Number of pages3
JournalAmerican Journal of Cardiology
Volume101
Issue number10
DOIs
StatePublished - May 15 2008

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Troponin
Endocarditis
Troponin I
Abscess
Central Nervous System
Left Ventricular Dysfunction
Hospital Mortality
Thoracic Surgery
Echocardiography
Staphylococcus aureus
Coronary Artery Disease
Diabetes Mellitus
Cohort Studies
Heart Failure
Prospective Studies
Kidney
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of Troponin Elevation to Outcome in Patients With Infective Endocarditis. / Purcell, Jonathan B.; Patel, Mahesh; Khera, Amit; de Lemos, James A; Forbess, Lisa; Baker, Sharon; Cabell, Christopher H.; Peterson, Gail E.

In: American Journal of Cardiology, Vol. 101, No. 10, 15.05.2008, p. 1479-1481.

Research output: Contribution to journalArticle

Purcell, Jonathan B. ; Patel, Mahesh ; Khera, Amit ; de Lemos, James A ; Forbess, Lisa ; Baker, Sharon ; Cabell, Christopher H. ; Peterson, Gail E. / Relation of Troponin Elevation to Outcome in Patients With Infective Endocarditis. In: American Journal of Cardiology. 2008 ; Vol. 101, No. 10. pp. 1479-1481.
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