Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study

Charlotte Andersson, Danielle Enserro, Lisa Sullivan, Thomas J. Wang, James L. Januzzi, Emelia J. Benjamin, Joseph A. Vita, Naomi M. Hamburg, Martin G. Larson, Gary F. Mitchell, Ramachandran S. Vasan

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s)ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 ± 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007-0.081] standard deviation [SD] change per SD increase in loge[GDF-15], p = 0.02) and FW (0.076 [0.026-0.126] SD change per SD increase in loge[GDF-15], p = 0.003) and inversely related to FMD (-0.051 [-0.101-0.0003] SD change per SD increase in loge[GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005-0.063] SD change per SD increase in loge[sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (-0.041 [-0.082-0.0004] SD change per SD increase in loge[hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalAtherosclerosis
Volume248
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Biomarkers
  • Endothelial function
  • GDF-15
  • General population
  • ST2
  • Troponin I
  • Vascular stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Andersson, C., Enserro, D., Sullivan, L., Wang, T. J., Januzzi, J. L., Benjamin, E. J., Vita, J. A., Hamburg, N. M., Larson, M. G., Mitchell, G. F., & Vasan, R. S. (2016). Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study. Atherosclerosis, 248, 245-251. https://doi.org/10.1016/j.atherosclerosis.2016.02.013