Objective: We sought to evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action. Study Design: Blood was obtained between 24-28 weeks (epoch 1) and 32-35 weeks (epoch 2) in 217 women with twin gestation receiving 17-OHPC or placebo. Gestational age at delivery and concentrations of 17-OHPC, 17-hydroxyprogesterone, progesterone, C-reactive protein (CRP), and corticotrophin-releasing hormone were assessed. Results: Women with higher concentrations of 17-OHPC delivered at earlier gestational ages than women with lower concentrations (P <.001). Women receiving 17-OHPC demonstrated significantly higher (P =.005) concentrations of CRP in epoch 1 than women receiving placebo but CRP values were similar in epoch 2 in both groups. A highly significant (P <.0001) positive relationship was observed between 17-OHPC concentration and progesterone and 17-hydroxyprogesterone concentrations at both epochs. Corticotropin-releasing hormone concentrations did not differ by treatment group. Conclusion: 17-OHPC may adversely impact gestational age at delivery in women with twin gestation.
- 17-hydroxyprogesterone caproate
- twin gestation
ASJC Scopus subject areas
- Obstetrics and Gynecology