Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation

Steve N. Caritis, Hyagriv N. Simhan, Yuan Zhao, Dwight J. Rouse, Alan M. Peaceman, Anthony Sciscione, Catherine Y. Spong, Michael W. Varner, Fergal D. Malone, Jay D. Iams, Brian M. Mercer, John M. Thorp, Yoram Sorokin, Marshall Carpenter, Julie Lo, Susan M. Ramin, Margaret Harper

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Objective: We sought to evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action. Study Design: Blood was obtained between 24-28 weeks (epoch 1) and 32-35 weeks (epoch 2) in 217 women with twin gestation receiving 17-OHPC or placebo. Gestational age at delivery and concentrations of 17-OHPC, 17-hydroxyprogesterone, progesterone, C-reactive protein (CRP), and corticotrophin-releasing hormone were assessed. Results: Women with higher concentrations of 17-OHPC delivered at earlier gestational ages than women with lower concentrations (P <.001). Women receiving 17-OHPC demonstrated significantly higher (P =.005) concentrations of CRP in epoch 1 than women receiving placebo but CRP values were similar in epoch 2 in both groups. A highly significant (P <.0001) positive relationship was observed between 17-OHPC concentration and progesterone and 17-hydroxyprogesterone concentrations at both epochs. Corticotropin-releasing hormone concentrations did not differ by treatment group. Conclusion: 17-OHPC may adversely impact gestational age at delivery in women with twin gestation.

Original languageEnglish (US)
Pages (from-to)396.e1-396.e8
JournalAmerican journal of obstetrics and gynecology
Volume207
Issue number5
DOIs
StatePublished - Nov 2012

Keywords

  • 17-hydroxyprogesterone caproate
  • pharmacodynamics
  • twin gestation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Caritis, S. N., Simhan, H. N., Zhao, Y., Rouse, D. J., Peaceman, A. M., Sciscione, A., Spong, C. Y., Varner, M. W., Malone, F. D., Iams, J. D., Mercer, B. M., Thorp, J. M., Sorokin, Y., Carpenter, M., Lo, J., Ramin, S. M., & Harper, M. (2012). Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation. American journal of obstetrics and gynecology, 207(5), 396.e1-396.e8. https://doi.org/10.1016/j.ajog.2012.08.001