Relationship between asthma and cognition: The cooper center longitudinal study

G. Caldera-Alvarado, D. A. Khan, L. F. Defina, A. Pieper, E. S. Brown

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods: We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results: When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions: In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume68
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Cognition
Longitudinal Studies
Asthma
Health Status
Adrenal Cortex Hormones
Cross-Sectional Studies
Logistic Models
Demography
Cognitive Dysfunction
Health

Keywords

  • asthma
  • cognition
  • corticosteroid
  • elderly
  • spirometry

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Relationship between asthma and cognition : The cooper center longitudinal study. / Caldera-Alvarado, G.; Khan, D. A.; Defina, L. F.; Pieper, A.; Brown, E. S.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 68, No. 4, 04.2013, p. 545-548.

Research output: Contribution to journalArticle

@article{2eeaae6848fc46c6970fc4bc38185112,
title = "Relationship between asthma and cognition: The cooper center longitudinal study",
abstract = "Background: Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods: We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results: When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78{\%} increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions: In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.",
keywords = "asthma, cognition, corticosteroid, elderly, spirometry",
author = "G. Caldera-Alvarado and Khan, {D. A.} and Defina, {L. F.} and A. Pieper and Brown, {E. S.}",
year = "2013",
month = "4",
doi = "10.1111/all.12125",
language = "English (US)",
volume = "68",
pages = "545--548",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Relationship between asthma and cognition

T2 - The cooper center longitudinal study

AU - Caldera-Alvarado, G.

AU - Khan, D. A.

AU - Defina, L. F.

AU - Pieper, A.

AU - Brown, E. S.

PY - 2013/4

Y1 - 2013/4

N2 - Background: Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods: We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results: When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions: In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.

AB - Background: Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment. Methods: We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable. Results: When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1/FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score. Conclusions: In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.

KW - asthma

KW - cognition

KW - corticosteroid

KW - elderly

KW - spirometry

UR - http://www.scopus.com/inward/record.url?scp=84875418603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875418603&partnerID=8YFLogxK

U2 - 10.1111/all.12125

DO - 10.1111/all.12125

M3 - Article

C2 - 23409872

AN - SCOPUS:84875418603

VL - 68

SP - 545

EP - 548

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 4

ER -