Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model

Masaya Takahashi, Felix W. Wehrli, Scott N. Hwang, Suzanne L. Wehrli

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The site-dependent variations in trabecular bone morphology were studied in the rat tibia by magnitude and phase difference three-dimensional nuclear magnetic resonance microscopy and image processing, and the implications of ovariectomy were evaluated. Specimens excised from the proximal tibial metaphysis in ovariectomized (n = 7) and intact control (n = 4) rats were imaged at 9.4T with their anatomic axes parallel to the direction of the magnetic field. An echo-offset 3D rapid spin-echo excitation pulse sequence was used to generate phase difference maps, from which the standard deviation of the phase difference, σ(Δφ), was calculated. In addition, a fictitious rate constant, R2/', was calculated from the slope of the exponential portion of the Fourier transform of the phase difference histogram. Trabecular bone volume fraction was also determined in the same volume of interest. The results show strong correlations between bone volume fraction and both σ(Δφ) and R2/', suggesting that these parameters could be useful for nondestructive assessment of trabecular bone volume.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalMagnetic Resonance Imaging
Volume18
Issue number1
DOIs
StatePublished - Jan 2000

Fingerprint

Ovariectomy
Magnetic Fields
bones
rats
Rats
Bone
Magnetic fields
magnetic fields
Volume fraction
echoes
Fourier Analysis
tibia
Tibia
Microscopy
Magnetic Resonance Spectroscopy
histograms
image processing
Bone and Bones
standard deviation
Rate constants

Keywords

  • NMR microscopy
  • Osteoporosis
  • Ovariectomy
  • Phase map
  • Trabecular bone

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. / Takahashi, Masaya; Wehrli, Felix W.; Hwang, Scott N.; Wehrli, Suzanne L.

In: Magnetic Resonance Imaging, Vol. 18, No. 1, 01.2000, p. 33-39.

Research output: Contribution to journalArticle

Takahashi, Masaya ; Wehrli, Felix W. ; Hwang, Scott N. ; Wehrli, Suzanne L. / Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. In: Magnetic Resonance Imaging. 2000 ; Vol. 18, No. 1. pp. 33-39.
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