Relationship between cytomegalovirus and colonization of the oropharynx by Gram-negative bacilli following renal transplantation

P. A. Mackowiack, M. Goggans, W. Torres, A. Dal Nogare, J. P. Luby, H. Helderman

Research output: Contribution to journalArticle

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Abstract

Numerous investigators have reported an increased incidence of pneumonia caused by Gram-negative bacilli and other secondary pathogens in transplant recipients infected by cytomegalovirus (CMV). To determine if CMV infections are related to colonization of the upper respiratory tract by Gram-negative bacilli, we examined prospectively 22 renal transplant recipients with sequential bacteriological, virological and biochemical examinations performed just prior to and at various times after transplantation. Only 11% of subjects had Gram-negative bacilli isolated from gargle specimens prior to transplantation, as compared to 54% after transplantation. More importantly, after transplantation, subjects with active CMV infections were more likely to have prolonged oropharyngeal carriage of Gram-negative bacilli than subjects without CMV infections (36% v. 25%). During active CMV infections, the rate at which Gram-negative bacilli were isolated from gargle specimens rose from 28 to 47%. During culture-positive CMV infections, the isolation rate reached 57% and was significantly different from that of CMV-negative samples (P < 0.01). The increased rate of Gram-negative bacillary isolation from gargle specimens during CMV infections was not a function of type of immunosuppresive agents used, rejection episodes, antibiotic administration, concomitant hepatitis B, Epstein Barr (EBV) virus, or herpes simplex virus infections, or alterations in salivary fibronectin concentrations.

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalEpidemiology and Infection
Volume107
Issue number2
StatePublished - 1991

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Oropharynx
Cytomegalovirus Infections
Cytomegalovirus
Kidney Transplantation
Bacillus
Transplantation
Human Herpesvirus 4
Virus Diseases
Simplexvirus
Hepatitis B
Fibronectins
Respiratory System
Pneumonia
Research Personnel
Anti-Bacterial Agents
Kidney
Incidence

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Relationship between cytomegalovirus and colonization of the oropharynx by Gram-negative bacilli following renal transplantation. / Mackowiack, P. A.; Goggans, M.; Torres, W.; Dal Nogare, A.; Luby, J. P.; Helderman, H.

In: Epidemiology and Infection, Vol. 107, No. 2, 1991, p. 411-420.

Research output: Contribution to journalArticle

Mackowiack, P. A. ; Goggans, M. ; Torres, W. ; Dal Nogare, A. ; Luby, J. P. ; Helderman, H. / Relationship between cytomegalovirus and colonization of the oropharynx by Gram-negative bacilli following renal transplantation. In: Epidemiology and Infection. 1991 ; Vol. 107, No. 2. pp. 411-420.
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