Abstract
Numerous investigators have reported an increased incidence of pneumonia caused by Gram-negative bacilli and other secondary pathogens in transplant recipients infected by cytomegalovirus (CMV). To determine if CMV infections are related to colonization of the upper respiratory tract by Gram-negative bacilli, we examined prospectively 22 renal transplant recipients with sequential bacteriological, virological and biochemical examinations performed just prior to and at various times after transplantation. Only 11% of subjects had Gram-negative bacilli isolated from gargle specimens prior to transplantation, as compared to 54% after transplantation. More importantly, after transplantation, subjects with active CMV infections were more likely to have prolonged oropharyngeal carriage of Gram-negative bacilli than subjects without CMV infections (36% v. 25%). During active CMV infections, the rate at which Gram-negative bacilli were isolated from gargle specimens rose from 28 to 47%. During culture-positive CMV infections, the isolation rate reached 57% and was significantly different from that of CMV-negative samples (P < 0.01). The increased rate of Gram-negative bacillary isolation from gargle specimens during CMV infections was not a function of type of immunosuppresive agents used, rejection episodes, antibiotic administration, concomitant hepatitis B, Epstein Barr (EBV) virus, or herpes simplex virus infections, or alterations in salivary fibronectin concentrations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 411-420 |
| Number of pages | 10 |
| Journal | Epidemiology and Infection |
| Volume | 107 |
| Issue number | 2 |
| State | Published - 1991 |
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ASJC Scopus subject areas
- Immunology
- Public Health, Environmental and Occupational Health
Cite this
Relationship between cytomegalovirus and colonization of the oropharynx by Gram-negative bacilli following renal transplantation. / Mackowiack, P. A.; Goggans, M.; Torres, W.; Dal Nogare, A.; Luby, J. P.; Helderman, H.
In: Epidemiology and Infection, Vol. 107, No. 2, 1991, p. 411-420.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between cytomegalovirus and colonization of the oropharynx by Gram-negative bacilli following renal transplantation
AU - Mackowiack, P. A.
AU - Goggans, M.
AU - Torres, W.
AU - Dal Nogare, A.
AU - Luby, J. P.
AU - Helderman, H.
PY - 1991
Y1 - 1991
N2 - Numerous investigators have reported an increased incidence of pneumonia caused by Gram-negative bacilli and other secondary pathogens in transplant recipients infected by cytomegalovirus (CMV). To determine if CMV infections are related to colonization of the upper respiratory tract by Gram-negative bacilli, we examined prospectively 22 renal transplant recipients with sequential bacteriological, virological and biochemical examinations performed just prior to and at various times after transplantation. Only 11% of subjects had Gram-negative bacilli isolated from gargle specimens prior to transplantation, as compared to 54% after transplantation. More importantly, after transplantation, subjects with active CMV infections were more likely to have prolonged oropharyngeal carriage of Gram-negative bacilli than subjects without CMV infections (36% v. 25%). During active CMV infections, the rate at which Gram-negative bacilli were isolated from gargle specimens rose from 28 to 47%. During culture-positive CMV infections, the isolation rate reached 57% and was significantly different from that of CMV-negative samples (P < 0.01). The increased rate of Gram-negative bacillary isolation from gargle specimens during CMV infections was not a function of type of immunosuppresive agents used, rejection episodes, antibiotic administration, concomitant hepatitis B, Epstein Barr (EBV) virus, or herpes simplex virus infections, or alterations in salivary fibronectin concentrations.
AB - Numerous investigators have reported an increased incidence of pneumonia caused by Gram-negative bacilli and other secondary pathogens in transplant recipients infected by cytomegalovirus (CMV). To determine if CMV infections are related to colonization of the upper respiratory tract by Gram-negative bacilli, we examined prospectively 22 renal transplant recipients with sequential bacteriological, virological and biochemical examinations performed just prior to and at various times after transplantation. Only 11% of subjects had Gram-negative bacilli isolated from gargle specimens prior to transplantation, as compared to 54% after transplantation. More importantly, after transplantation, subjects with active CMV infections were more likely to have prolonged oropharyngeal carriage of Gram-negative bacilli than subjects without CMV infections (36% v. 25%). During active CMV infections, the rate at which Gram-negative bacilli were isolated from gargle specimens rose from 28 to 47%. During culture-positive CMV infections, the isolation rate reached 57% and was significantly different from that of CMV-negative samples (P < 0.01). The increased rate of Gram-negative bacillary isolation from gargle specimens during CMV infections was not a function of type of immunosuppresive agents used, rejection episodes, antibiotic administration, concomitant hepatitis B, Epstein Barr (EBV) virus, or herpes simplex virus infections, or alterations in salivary fibronectin concentrations.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025990851&partnerID=8YFLogxK
M3 - Article
C2 - 1657624
AN - SCOPUS:0025990851
VL - 107
SP - 411
EP - 420
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 2
ER -