Relationship between cytomegalovirus and hepatic function abnormalities in the period after renal transplant

J. P. Luby, W. Burnett, A. R. Hull, A. J. Ware, J. W. Shorey, P. C. Peters

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Forty five consecutive recipients of renal transplants have been studied for 3 to 18 mth (average time, 9.5 mth). Sera were collected before transplant and at 1,2,3,6,9,12,15 and 18 months and tested for complement fixation antibody against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV1). Before transplantation 34.3% had CMV titers ≥1:4, while the comparable figure for HSV1 was 42.9%. After transplantation 72.7% had four fold or greater rises in CMV titer, while only 18.2% had such rises to HSV1. Twenty of 44 patients (45.4%) developed chemical evidence of hepatitis following transplantation. Nine of the 20 had hepatitis B antigen positive hepatitis. Nine of the remaining 11 patients had onset of hepatitis when they were undergoing CMV seroconversion. The attack rate of hepatitis B antigen negative hepatitis was higher in persons who had greater maximal rises in antibody titer to CMV. Thirteen of the 20 cases, including 5 associated temporally with CMV seroconversion, had evidence of continuing hepatic dysfunction at and beyond 120 days. The study indicates comparability of initial prevalence of antibody to CMV and HSV1 despite transfusion of an average of 7.7 units per person (predominantly leukocyte poor blood) within 3 mth of transplant. CMV may be an important cause of hepatic function abnormalities after renal transplant, and some of the changes induced may be chronic. (25 references).

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalUnknown Journal
Volume129
Issue number5
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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