Relationship between cytomegalovirus and hepatic function abnormalities in the period after renal transplant

J. P. Luby, W. Burnett, A. R. Hull, A. J. Ware, J. W. Shorey, P. C. Peters

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Abstract

Forty five consecutive recipients of renal transplants have been studied for 3 to 18 mth (average time, 9.5 mth). Sera were collected before transplant and at 1,2,3,6,9,12,15 and 18 months and tested for complement fixation antibody against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV 1). Before transplantation 34.3% had CMV titers ≥1:4, while the comparable figure for HSV 1 was 42.9%. After transplantation 72.7% had four fold or greater rises in CMV titer, while only 18.2% had such rises to HSV 1. Twenty of 44 patients (45.4%) developed chemical evidence of hepatitis following transplantation. Nine of the 20 had hepatitis B antigen positive hepatitis. Nine of the remaining 11 patients had onset of hepatitis when they were undergoing CMV seroconversion. The attack rate of hepatitis B antigen negative hepatitis was higher in persons who had greater maximal rises in antibody titer to CMV. Thirteen of the 20 cases, including 5 associated temporally with CMV seroconversion, had evidence of continuing hepatic dysfunction at and beyond 120 days. The study indicates comparability of initial prevalence of antibody to CMV and HSV 1 despite transfusion of an average of 7.7 units per person (predominantly leukocyte poor blood) within 3 mth of transplant. CMV may be an important cause of hepatic function abnormalities after renal transplant, and some of the changes induced may be chronic. (25 references).

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalJournal of Infectious Diseases
Volume129
Issue number5
StatePublished - 1974

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Cytomegalovirus
Transplants
Kidney
Liver
Human Herpesvirus 1
Hepatitis
Hepatitis B Antigens
Transplantation
Antibodies
Leukocytes
Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Relationship between cytomegalovirus and hepatic function abnormalities in the period after renal transplant. / Luby, J. P.; Burnett, W.; Hull, A. R.; Ware, A. J.; Shorey, J. W.; Peters, P. C.

In: Journal of Infectious Diseases, Vol. 129, No. 5, 1974, p. 511-518.

Research output: Contribution to journalArticle

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AU - Luby, J. P.

AU - Burnett, W.

AU - Hull, A. R.

AU - Ware, A. J.

AU - Shorey, J. W.

AU - Peters, P. C.

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