Relationship between inflammatory biomarker galectin-3 and hippocampal volume in a community study

Megan K. Lowther, Jarrod P. Tunnell, Jayme M. Palka, Darlene R. King, Damilola C. Salako, Dimitri G. Macris, Jay B. Italiya, Justin L. Grodin, Carol S. North, E. Sherwood Brown

Research output: Contribution to journalArticlepeer-review

Abstract

Galectin-3 (Gal3) is expressed by microglia and performs functions including adhesion; activation of macrophages and fibroblasts, and mediates inflammatory responses in the hippocampus. The present study examined whether serum Gal3 levels predict hippocampal volume in a multi-ethnic, community-based sample. Results of a multiple linear regression (controlling for depression, serum creatinine level, age, BMI, total brain volume, MoCA score, sex, ethnicity, smoking status, history of diabetes) showed that Gal3 levels significantly predicted left (p = .027) but not right hippocampal volume. The relationship was stronger in men than women. Findings suggest this novel inflammatory biomarker is associated with human hippocampal volume.

Original languageEnglish (US)
Article number577386
JournalJournal of Neuroimmunology
Volume348
DOIs
StatePublished - Nov 15 2020

Keywords

  • Dallas heart study
  • Galectin-3
  • Hippocampus
  • Memory
  • Neuroinflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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