Relationship between insulin sensitivity, hyperinsulinemia, and insulin-mediated sympathetic activation in normotensive and hypertensive subjects

Carlos Arauz-Pacheco, Dan Lender, Peter G. Snell, Beverley A Huet, Luis C. Ramirez, Laura Breen, Pablo Mora, Philip Raskin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The adrenergic response to high physiological hyperinsulinemia was studied in 39 hypertensive subjects (28 men and 11 women) and 25 normal volunteers (15 men and 10 women), using the euglycemic clamp technique. Control studies using 0.45% saline infusions (sham studies) were also performed. Before and during the clamp procedure, plasma norepinephrine (NE) and epinephrine (E) were measured using a high performance liquid chromatographic method (HPLC). The association between the increment in NE and E levels and insulin sensitivity, steady state insulin level during the clamps, waist to hip ratio (WHR), baseline NE levels and gender was studied. NE levels increased during the hyperinsulinemic period (mean increase 46 ± 6 pmol P < .001 v baseline and P < .01 v sham studies). E levels did not differ between the insulin clamps and the sham studies. Insulin sensitivity was not significantly associated with the increment in NE. Hypertensive subjects had a higher NE increase than the normotensive individuals (55 ± 7 v 30 ± 10 pmol, P = .03), but also had higher insulin levels during the clamps (839 ± 43 v 522 ± 38 pmol, P < .001). Insulin levels accounted for most of the differences in NE increase between the normotensive and hypertensive groups. Gender, adiposity and WHR were also associated with NE increment. We conclude that the insulin mediated sympathetic activation is not affected in the presence of decreased insulin sensitivity for glucose utilization. The greater degree of sympathetic activation observed in hypertensive subjects is a function of the level of insulinemia obtained during the clamps.

Original languageEnglish (US)
Pages (from-to)1172-1178
Number of pages7
JournalAmerican Journal of Hypertension
Volume9
Issue number12 I
DOIs
StatePublished - Dec 1996

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Hyperinsulinism
Insulin Resistance
Norepinephrine
Insulin
Waist-Hip Ratio
Glucose Clamp Technique
Adiposity
Adrenergic Agents
Epinephrine
Healthy Volunteers
Glucose

Keywords

  • blood
  • euglycemic clamps
  • hypertension
  • insulin resistance
  • norepinephrine
  • sympathetic nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relationship between insulin sensitivity, hyperinsulinemia, and insulin-mediated sympathetic activation in normotensive and hypertensive subjects. / Arauz-Pacheco, Carlos; Lender, Dan; Snell, Peter G.; Huet, Beverley A; Ramirez, Luis C.; Breen, Laura; Mora, Pablo; Raskin, Philip.

In: American Journal of Hypertension, Vol. 9, No. 12 I, 12.1996, p. 1172-1178.

Research output: Contribution to journalArticle

Arauz-Pacheco, Carlos ; Lender, Dan ; Snell, Peter G. ; Huet, Beverley A ; Ramirez, Luis C. ; Breen, Laura ; Mora, Pablo ; Raskin, Philip. / Relationship between insulin sensitivity, hyperinsulinemia, and insulin-mediated sympathetic activation in normotensive and hypertensive subjects. In: American Journal of Hypertension. 1996 ; Vol. 9, No. 12 I. pp. 1172-1178.
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