Relationship between treatment persistence and A1C trends among patients with type 2 diabetes newly initiating basal insulin

Fang Liz Zhou, Lin Xie, Chunshen Pan, Yuexi Wang, Neel Vaidya, Fen Ye, Ronald Preblick, Luigi Meneghini

Research output: Contribution to journalArticle

3 Scopus citations


This study examines the relationship between glycated haemoglobin (A1C) levels and treatment persistence with, or time to discontinuation of, basal insulin in patients with type 2 diabetes (T2D) newly initiating insulin. Claims data were extracted from the Optum Clinformatics database from January 2010 to June 2015. Adult patients with T2D initiating insulin glargine 100U/mL (Gla-100) or insulin detemir (DET) with ≥1 A1C measurement during 12-month baseline and 18-month follow-up periods were included. Patients with a refill gap of >90days were considered non-persistent; otherwise, patients were considered persistent with insulin. The main outcome was A1C, measured closest to the end of each quarter during the follow-up period. A total of 3993 of 109934 patients met the inclusion criteria (43.0% persistent; 57.0% non-persistent). Persistent patients were older (54.7 vs 52.7 years; P <.001), were more likely to be male (59.4% vs 54.4%; P =.002), and had significantly lower mean unadjusted A1C values at 18months (8.26% vs 8.60%; P <.001) and quarterly. Only 43.0% of adults initiating basal insulin persisted with treatment for 18months, with earlier discontinuation associated with higher A1C.

Original languageEnglish (US)
JournalDiabetes, Obesity and Metabolism
StateAccepted/In press - Jan 1 2018



  • Basal insulin
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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