Relationship of brain and skull in pre- and postoperative sagittal synostosis

Kristina Aldridge, Alex A. Kane, Jeffrey L. Marsh, Peng Yan, Daniel Govier, Joan T. Richtsmeier

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Models of vertebrate skull evolution stress the coordinated developmental relationship between the skull and the brain that it houses. This study investigates the relationship between altered skull morphology and brain morphology in premature fusion of the cranial sagittal suture (isolated sagittal synostosis; ISS), a condition associated with dysmorphology of both neurocranium and brain. Although the skull displays a more normal shape following reconstructive cranial vault surgery, effects of this surgery on the brain have not been investigated. Landmark coordinate data were collected from three-dimensional magnetic resonance imaging reconstructions of the brain in a sample of ISS patients and an age-matched unaffected cohort. These data were analysed using Euclidean distance matrix analysis (EDMA). Results show that the brain in ISS is dysmorphic preoperatively, displaying a posteriorly directed neural expansion that does not 'worsen' with growth. Postoperatively, the brain in ISS displays a more globular shape overall as compared with the preoperative morphology, but differs from normal in its subcortical morphology. These results show that the ISS brain is altered following neurocranial surgery, but does not more closely approximate that of unaffected individuals. This suggests that although the brain is affected by manipulation of the skull, it retains a growth pattern that is, at least in part, independent of the skull.

Original languageEnglish (US)
Pages (from-to)373-385
Number of pages13
JournalJournal of Anatomy
Volume206
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Craniosynostoses
skull
Skull
brain
Brain
surgery
Cranial Sutures
sutures
Growth
magnetic resonance imaging
Vertebrates
vertebrate
vertebrates
Magnetic Resonance Imaging
matrix

Keywords

  • Craniosynostosis
  • Shape
  • Skull
  • Suture

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Relationship of brain and skull in pre- and postoperative sagittal synostosis. / Aldridge, Kristina; Kane, Alex A.; Marsh, Jeffrey L.; Yan, Peng; Govier, Daniel; Richtsmeier, Joan T.

In: Journal of Anatomy, Vol. 206, No. 4, 04.2005, p. 373-385.

Research output: Contribution to journalArticle

Aldridge, K, Kane, AA, Marsh, JL, Yan, P, Govier, D & Richtsmeier, JT 2005, 'Relationship of brain and skull in pre- and postoperative sagittal synostosis', Journal of Anatomy, vol. 206, no. 4, pp. 373-385. https://doi.org/10.1111/j.1469-7580.2005.00397.x
Aldridge, Kristina ; Kane, Alex A. ; Marsh, Jeffrey L. ; Yan, Peng ; Govier, Daniel ; Richtsmeier, Joan T. / Relationship of brain and skull in pre- and postoperative sagittal synostosis. In: Journal of Anatomy. 2005 ; Vol. 206, No. 4. pp. 373-385.
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