Relationship of butaperazine blood levels to plasma prolactin in chronic schizophrenic patients

Robert C. Smith, Carol A. Tamminga, John W. Crayton, Haroutune Dekirmenjian, John M. Davis

Research output: Contribution to journalArticle

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Abstract

The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalPsychopharmacology
Volume66
Issue number1
DOIs
StatePublished - Nov 1 1979

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Keywords

  • Blood levels
  • Butaperazine
  • Prolactin

ASJC Scopus subject areas

  • Pharmacology

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