TY - JOUR
T1 - Relationship of glucagon suppression by insulin and somatostatin to the ambient glucose concentration
AU - Starke, A.
AU - Imamura, T.
AU - Unger, Roger H
PY - 1987
Y1 - 1987
N2 - The glucagon-suppressing activity of insulin and somatostatin were compared at high and low glucose concentrations. In normal dogs made hyperglucagonemic by phloridzin pretreatment, insulin and somatostatin suppressed glucagon at rates of 47 ± 8 and 35 ± 8%/h (NS), respectively, despite profound hypoglycemia. In severely hyperglycemic alloxan-diabetic dogs, insulin and somatostatin suppressed glucagon at rates of 48 ± 13 and 54 ± 6%/h, respectively, not different from the nondiabetic dogs. After phloridzin pretreatment to eliminate hyperglycemia in the diabetic dogs, insulin and somatostatin suppressed 51 ± 8 and 31 ± 10%/h (NS), respectively. Glucose infused in the phloridzin-pretreated insulin-deprived group suppressed glucagon only partially; insulin was required to reduce it further. We conclude (a) that insulin and somatostatin suppress glucagon at similar rates irrespective of ambient glucose levels, and (b) that diabetic hyperglucagonemia represents the summation of stimulation by insulin lack minus suppression by the associated hyperglycemia.
AB - The glucagon-suppressing activity of insulin and somatostatin were compared at high and low glucose concentrations. In normal dogs made hyperglucagonemic by phloridzin pretreatment, insulin and somatostatin suppressed glucagon at rates of 47 ± 8 and 35 ± 8%/h (NS), respectively, despite profound hypoglycemia. In severely hyperglycemic alloxan-diabetic dogs, insulin and somatostatin suppressed glucagon at rates of 48 ± 13 and 54 ± 6%/h, respectively, not different from the nondiabetic dogs. After phloridzin pretreatment to eliminate hyperglycemia in the diabetic dogs, insulin and somatostatin suppressed 51 ± 8 and 31 ± 10%/h (NS), respectively. Glucose infused in the phloridzin-pretreated insulin-deprived group suppressed glucagon only partially; insulin was required to reduce it further. We conclude (a) that insulin and somatostatin suppress glucagon at similar rates irrespective of ambient glucose levels, and (b) that diabetic hyperglucagonemia represents the summation of stimulation by insulin lack minus suppression by the associated hyperglycemia.
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U2 - 10.1172/JCI112784
DO - 10.1172/JCI112784
M3 - Article
C2 - 2878938
AN - SCOPUS:0023155639
SN - 0021-9738
VL - 79
SP - 20
EP - 24
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 1
ER -