Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction

Husam M. Salah; Ambarish Pandey; Anzhela Soloveva; Manal F. Abdelmalek; Anna Mae Diehl; Cynthia A. Moylan; Kara Wegermann; Vishal N. Rao; Adrian F. Hernandez; Ryan J. Tedford; Kishan S. Parikh; Robert J. Mentz; Robert W. McGarrah; Marat Fudim

doi:10.1016/j.jacbts.2021.07.010

Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction

Husam M. Salah, Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, Vishal N. Rao, Adrian F. Hernandez, Ryan J. Tedford, Kishan S. Parikh, Robert J. Mentz, Robert W. McGarrah, Marat Fudim

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

Although there is an established bidirectional relationship between heart failure with reduced ejection fraction and liver disease, the association between heart failure with preserved ejection fraction (HFpEF) and liver diseases, such as nonalcoholic fatty liver disease (NAFLD), has not been well explored. In this paper, the authors provide an in-depth review of the relationship between HFpEF and NAFLD and propose 3 NAFLD-related HFpEF phenotypes (obstructive HFpEF, metabolic HFpEF, and advanced liver fibrosis HFpEF). The authors also discuss diagnostic challenges related to the concurrent presence of NAFLD and HFpEF and offer several treatment options for NAFLD-related HFpEF phenotypes. The authors propose that NAFLD-related HFpEF should be recognized as a distinct HFpEF phenotype.

Original language	English (US)
Pages (from-to)	918-932
Number of pages	15
Journal	JACC: Basic to Translational Science
Volume	6
Issue number	11
DOIs	https://doi.org/10.1016/j.jacbts.2021.07.010
State	Published - Nov 2021

Keywords

HFpEF
NAFLD
cardiomyopathy
heart failure
liver

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2021.07.010

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Salah, H. M., Pandey, A., Soloveva, A., Abdelmalek, M. F., Diehl, A. M., Moylan, C. A., Wegermann, K., Rao, V. N., Hernandez, A. F., Tedford, R. J., Parikh, K. S., Mentz, R. J., McGarrah, R. W., & Fudim, M. (2021). Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction. JACC: Basic to Translational Science, 6(11), 918-932. https://doi.org/10.1016/j.jacbts.2021.07.010

Salah, HM, Pandey, A, Soloveva, A, Abdelmalek, MF, Diehl, AM, Moylan, CA, Wegermann, K, Rao, VN, Hernandez, AF, Tedford, RJ, Parikh, KS, Mentz, RJ, McGarrah, RW & Fudim, M 2021, 'Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction', JACC: Basic to Translational Science, vol. 6, no. 11, pp. 918-932. https://doi.org/10.1016/j.jacbts.2021.07.010

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title = "Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction",

abstract = "Although there is an established bidirectional relationship between heart failure with reduced ejection fraction and liver disease, the association between heart failure with preserved ejection fraction (HFpEF) and liver diseases, such as nonalcoholic fatty liver disease (NAFLD), has not been well explored. In this paper, the authors provide an in-depth review of the relationship between HFpEF and NAFLD and propose 3 NAFLD-related HFpEF phenotypes (obstructive HFpEF, metabolic HFpEF, and advanced liver fibrosis HFpEF). The authors also discuss diagnostic challenges related to the concurrent presence of NAFLD and HFpEF and offer several treatment options for NAFLD-related HFpEF phenotypes. The authors propose that NAFLD-related HFpEF should be recognized as a distinct HFpEF phenotype.",

keywords = "HFpEF, NAFLD, cardiomyopathy, heart failure, liver",

author = "Salah, {Husam M.} and Ambarish Pandey and Anzhela Soloveva and Abdelmalek, {Manal F.} and Diehl, {Anna Mae} and Moylan, {Cynthia A.} and Kara Wegermann and Rao, {Vishal N.} and Hernandez, {Adrian F.} and Tedford, {Ryan J.} and Parikh, {Kishan S.} and Mentz, {Robert J.} and McGarrah, {Robert W.} and Marat Fudim",

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year = "2021",

month = nov,

doi = "10.1016/j.jacbts.2021.07.010",

language = "English (US)",

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AU - Salah, Husam M.

AU - Pandey, Ambarish

AU - Soloveva, Anzhela

AU - Abdelmalek, Manal F.

AU - Diehl, Anna Mae

AU - Moylan, Cynthia A.

AU - Wegermann, Kara

AU - Rao, Vishal N.

AU - Hernandez, Adrian F.

AU - Tedford, Ryan J.

AU - Parikh, Kishan S.

AU - Mentz, Robert J.

AU - McGarrah, Robert W.

AU - Fudim, Marat

PY - 2021/11

Y1 - 2021/11

N2 - Although there is an established bidirectional relationship between heart failure with reduced ejection fraction and liver disease, the association between heart failure with preserved ejection fraction (HFpEF) and liver diseases, such as nonalcoholic fatty liver disease (NAFLD), has not been well explored. In this paper, the authors provide an in-depth review of the relationship between HFpEF and NAFLD and propose 3 NAFLD-related HFpEF phenotypes (obstructive HFpEF, metabolic HFpEF, and advanced liver fibrosis HFpEF). The authors also discuss diagnostic challenges related to the concurrent presence of NAFLD and HFpEF and offer several treatment options for NAFLD-related HFpEF phenotypes. The authors propose that NAFLD-related HFpEF should be recognized as a distinct HFpEF phenotype.

AB - Although there is an established bidirectional relationship between heart failure with reduced ejection fraction and liver disease, the association between heart failure with preserved ejection fraction (HFpEF) and liver diseases, such as nonalcoholic fatty liver disease (NAFLD), has not been well explored. In this paper, the authors provide an in-depth review of the relationship between HFpEF and NAFLD and propose 3 NAFLD-related HFpEF phenotypes (obstructive HFpEF, metabolic HFpEF, and advanced liver fibrosis HFpEF). The authors also discuss diagnostic challenges related to the concurrent presence of NAFLD and HFpEF and offer several treatment options for NAFLD-related HFpEF phenotypes. The authors propose that NAFLD-related HFpEF should be recognized as a distinct HFpEF phenotype.

KW - HFpEF

KW - NAFLD

KW - cardiomyopathy

KW - heart failure

KW - liver

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Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction

Abstract

Keywords

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