Relationship of Nonalcoholic Fatty Liver Disease and Heart Failure With Preserved Ejection Fraction

Husam M. Salah, Ambarish Pandey, Anzhela Soloveva, Manal F. Abdelmalek, Anna Mae Diehl, Cynthia A. Moylan, Kara Wegermann, Vishal N. Rao, Adrian F. Hernandez, Ryan J. Tedford, Kishan S. Parikh, Robert J. Mentz, Robert W. McGarrah, Marat Fudim

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Although there is an established bidirectional relationship between heart failure with reduced ejection fraction and liver disease, the association between heart failure with preserved ejection fraction (HFpEF) and liver diseases, such as nonalcoholic fatty liver disease (NAFLD), has not been well explored. In this paper, the authors provide an in-depth review of the relationship between HFpEF and NAFLD and propose 3 NAFLD-related HFpEF phenotypes (obstructive HFpEF, metabolic HFpEF, and advanced liver fibrosis HFpEF). The authors also discuss diagnostic challenges related to the concurrent presence of NAFLD and HFpEF and offer several treatment options for NAFLD-related HFpEF phenotypes. The authors propose that NAFLD-related HFpEF should be recognized as a distinct HFpEF phenotype.

Original languageEnglish (US)
Pages (from-to)918-932
Number of pages15
JournalJACC: Basic to Translational Science
Issue number11
StatePublished - Nov 2021


  • HFpEF
  • cardiomyopathy
  • heart failure
  • liver

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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