Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women

A. N. Peiris, R. K. Thakur, M. S. Sothmann, A. B. Gustafson, M. I. Hennes, C. R. Wilson, A. H. Kissebah

Research output: Contribution to journalArticle

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Abstract

Abdominal obesity is an independent cardiovascular risk factor. The coexistence of abdominal obesity and electrocardiographic abnormalities may facilitate the development of cardiac arrhythmias and sudden death. We determined the relationship of body fat distribution and obesity to ECG indices in 27 obese premenopausal women on an isocaloric diet. Intra-abdominal fat distribution was assessed by computerized tomography, and obesity was assessed by hydrostatic weighing. The PR, QRS, and QT(c) intervals, the P and QRS axes, and the P-QRS angle were determined from a resting electrocardiogram. Cardiovascular risk profile was assessed by systolic and diastolic blood pressure and plasma cholesterol and triglyceride levels. Increased deposition of intra-abdominal fat was significantly associated with prolongation of the QT(c) interval independent of obesity and other cardiovascular risk factors. The prolongation of the QT(c) interval seen with increasing intra-abdominal fat distribution may enhance susceptibility to cardiac arrhythmias. These subjects should have electrocardiographic monitoring during periods of weight loss achieved by intensive regimens.

Original languageEnglish (US)
Pages (from-to)961-965
Number of pages5
JournalSouthern Medical Journal
Volume84
Issue number8
StatePublished - 1991

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Intra-Abdominal Fat
Abdominal Obesity
Obesity
Fats
Cardiac Arrhythmias
Electrocardiography
Blood Pressure
Body Fat Distribution
Sudden Death
Weight Loss
Triglycerides
Cholesterol
Tomography
Diet

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Peiris, A. N., Thakur, R. K., Sothmann, M. S., Gustafson, A. B., Hennes, M. I., Wilson, C. R., & Kissebah, A. H. (1991). Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women. Southern Medical Journal, 84(8), 961-965.

Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women. / Peiris, A. N.; Thakur, R. K.; Sothmann, M. S.; Gustafson, A. B.; Hennes, M. I.; Wilson, C. R.; Kissebah, A. H.

In: Southern Medical Journal, Vol. 84, No. 8, 1991, p. 961-965.

Research output: Contribution to journalArticle

Peiris, AN, Thakur, RK, Sothmann, MS, Gustafson, AB, Hennes, MI, Wilson, CR & Kissebah, AH 1991, 'Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women', Southern Medical Journal, vol. 84, no. 8, pp. 961-965.
Peiris, A. N. ; Thakur, R. K. ; Sothmann, M. S. ; Gustafson, A. B. ; Hennes, M. I. ; Wilson, C. R. ; Kissebah, A. H. / Relationship of regional fat distribution and obesity to electrocardiographic parameters in healthy premenopausal women. In: Southern Medical Journal. 1991 ; Vol. 84, No. 8. pp. 961-965.
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