Relationships among bleeding severity, health-related quality of life, and platelet count in children with immune thrombocytopenic purpura

Cindy E. Neunert; George R. Buchanan; Victor Blanchette; Dorothy Barnard; Nancy L. Young; Christine Curtis; Robert J. Klaassen

doi:10.1002/pbc.21978

Relationships among bleeding severity, health-related quality of life, and platelet count in children with immune thrombocytopenic purpura

Cindy E. Neunert, George R. Buchanan, Victor Blanchette, Dorothy Barnard, Nancy L. Young, Christine Curtis, Robert J. Klaassen

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Important outcomes for children with immune thrombocytopenic purpura (ITP) include health-related quality of life (HRQOL) and bleeding severity. A HRQOL instrument for children with ITP, the Kids' ITP Tools (KIT), was recently validated. Secondary analysis of the KIT database was performed to determine relationships among platelet count, bleeding severity and HRQOL. Bleeding severity grade correlated with platelet count in chronic ITP but not in acute ITP. Platelet count and bleeding severity failed to have any statistically significant correlations with the KIT scores. These findings suggest that relationships among outcome measures in children with ITP, using currently available instruments, remain poorly defined.

Original language	English (US)
Pages (from-to)	652-654
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	53
Issue number	4
DOIs	https://doi.org/10.1002/pbc.21978
State	Published - Oct 2009

Keywords

Bleeding severity
ITP
Quality of life

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.21978

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abstract = "Important outcomes for children with immune thrombocytopenic purpura (ITP) include health-related quality of life (HRQOL) and bleeding severity. A HRQOL instrument for children with ITP, the Kids' ITP Tools (KIT), was recently validated. Secondary analysis of the KIT database was performed to determine relationships among platelet count, bleeding severity and HRQOL. Bleeding severity grade correlated with platelet count in chronic ITP but not in acute ITP. Platelet count and bleeding severity failed to have any statistically significant correlations with the KIT scores. These findings suggest that relationships among outcome measures in children with ITP, using currently available instruments, remain poorly defined.",

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AU - Neunert, Cindy E.

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AU - Barnard, Dorothy

AU - Young, Nancy L.

AU - Curtis, Christine

AU - Klaassen, Robert J.

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AB - Important outcomes for children with immune thrombocytopenic purpura (ITP) include health-related quality of life (HRQOL) and bleeding severity. A HRQOL instrument for children with ITP, the Kids' ITP Tools (KIT), was recently validated. Secondary analysis of the KIT database was performed to determine relationships among platelet count, bleeding severity and HRQOL. Bleeding severity grade correlated with platelet count in chronic ITP but not in acute ITP. Platelet count and bleeding severity failed to have any statistically significant correlations with the KIT scores. These findings suggest that relationships among outcome measures in children with ITP, using currently available instruments, remain poorly defined.

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Relationships among bleeding severity, health-related quality of life, and platelet count in children with immune thrombocytopenic purpura

Abstract

Keywords

ASJC Scopus subject areas

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