Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function

William Todd Cade, Edgar Turner Overton, Kristin Mondy, Lisa De Las Fuentes, Victor G. Davila-Roman, Alan D. Waggoner, Dominic N. Reeds, Sherry Lassa-Claxton, Melissa J. Krauss, Linda R. Peterson, Kevin E. Yarasheski

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Abstract

Our objective was to determine if the presence of metabolic complications (MC) conveyed an additional risk for left ventricular (LV) dysfunction in people with HIV. HIV+ and HIV- men and women were categorized into four groups: (1) HIV+ with MC (43±7 years, n=64), (2) HIV+ without MC (42±7 years, n=59), (3) HIV- with MC (44±8 years, n=37), or (4) HIV- controls without MC (42±8 years, n=41). All participants underwent two-dimensional (2-D), Doppler, and tissue Doppler echocardiography. Overall, the prevalence of systolic dysfunction (15 vs. 4%, p=0.02) and LV hypertrophy (9 vs. 1%, p=0.03) was greater in HIV+ than in HIV- participants. Participants with MC had a greater prevalence of LV hypertrophy (10% vs. 1%). Early mitral annular velocity during diastole was significantly (p<0.005) lower in groups with MC (HIV+/MC+: 11.6±2.3, HIV-/MC+: 12.0±2.3 vs. HIV+/MC -: 12.4±2.3, HIV-/MC-: 13.1±2.4 cm/s) and tended to be lower in groups with HIV (p=0.10). However, there was no interaction effect of HIV and MC for any systolic or diastolic variable. Regardless of HIV status, participants with MC had reduced LV diastolic function. Although both the presence of MC and HIV infection were associated with lower diastolic function, there was no additive negative effect of HIV on diastolic function beyond the effect of MC. Also, HIV was independently associated with lower systolic function. Clinical monitoring of LV function in individuals with metabolic risk factors, regardless of HIV status, is warranted.

Original languageEnglish (US)
Pages (from-to)1151-1160
Number of pages10
JournalAIDS Research and Human Retroviruses
Volume29
Issue number8
DOIs
StatePublished - Aug 1 2013

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Left Ventricular Function
HIV Infections
HIV
Left Ventricular Hypertrophy
HIV-2
Diastole
Doppler Echocardiography
Left Ventricular Dysfunction
HIV-1

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Cade, W. T., Overton, E. T., Mondy, K., Fuentes, L. D. L., Davila-Roman, V. G., Waggoner, A. D., ... Yarasheski, K. E. (2013). Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function. AIDS Research and Human Retroviruses, 29(8), 1151-1160. https://doi.org/10.1089/aid.2012.0254

Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function. / Cade, William Todd; Overton, Edgar Turner; Mondy, Kristin; Fuentes, Lisa De Las; Davila-Roman, Victor G.; Waggoner, Alan D.; Reeds, Dominic N.; Lassa-Claxton, Sherry; Krauss, Melissa J.; Peterson, Linda R.; Yarasheski, Kevin E.

In: AIDS Research and Human Retroviruses, Vol. 29, No. 8, 01.08.2013, p. 1151-1160.

Research output: Contribution to journalArticle

Cade, WT, Overton, ET, Mondy, K, Fuentes, LDL, Davila-Roman, VG, Waggoner, AD, Reeds, DN, Lassa-Claxton, S, Krauss, MJ, Peterson, LR & Yarasheski, KE 2013, 'Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function', AIDS Research and Human Retroviruses, vol. 29, no. 8, pp. 1151-1160. https://doi.org/10.1089/aid.2012.0254
Cade, William Todd ; Overton, Edgar Turner ; Mondy, Kristin ; Fuentes, Lisa De Las ; Davila-Roman, Victor G. ; Waggoner, Alan D. ; Reeds, Dominic N. ; Lassa-Claxton, Sherry ; Krauss, Melissa J. ; Peterson, Linda R. ; Yarasheski, Kevin E. / Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function. In: AIDS Research and Human Retroviruses. 2013 ; Vol. 29, No. 8. pp. 1151-1160.
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abstract = "Our objective was to determine if the presence of metabolic complications (MC) conveyed an additional risk for left ventricular (LV) dysfunction in people with HIV. HIV+ and HIV- men and women were categorized into four groups: (1) HIV+ with MC (43±7 years, n=64), (2) HIV+ without MC (42±7 years, n=59), (3) HIV- with MC (44±8 years, n=37), or (4) HIV- controls without MC (42±8 years, n=41). All participants underwent two-dimensional (2-D), Doppler, and tissue Doppler echocardiography. Overall, the prevalence of systolic dysfunction (15 vs. 4{\%}, p=0.02) and LV hypertrophy (9 vs. 1{\%}, p=0.03) was greater in HIV+ than in HIV- participants. Participants with MC had a greater prevalence of LV hypertrophy (10{\%} vs. 1{\%}). Early mitral annular velocity during diastole was significantly (p<0.005) lower in groups with MC (HIV+/MC+: 11.6±2.3, HIV-/MC+: 12.0±2.3 vs. HIV+/MC -: 12.4±2.3, HIV-/MC-: 13.1±2.4 cm/s) and tended to be lower in groups with HIV (p=0.10). However, there was no interaction effect of HIV and MC for any systolic or diastolic variable. Regardless of HIV status, participants with MC had reduced LV diastolic function. Although both the presence of MC and HIV infection were associated with lower diastolic function, there was no additive negative effect of HIV on diastolic function beyond the effect of MC. Also, HIV was independently associated with lower systolic function. Clinical monitoring of LV function in individuals with metabolic risk factors, regardless of HIV status, is warranted.",
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AU - Waggoner, Alan D.

AU - Reeds, Dominic N.

AU - Lassa-Claxton, Sherry

AU - Krauss, Melissa J.

AU - Peterson, Linda R.

AU - Yarasheski, Kevin E.

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N2 - Our objective was to determine if the presence of metabolic complications (MC) conveyed an additional risk for left ventricular (LV) dysfunction in people with HIV. HIV+ and HIV- men and women were categorized into four groups: (1) HIV+ with MC (43±7 years, n=64), (2) HIV+ without MC (42±7 years, n=59), (3) HIV- with MC (44±8 years, n=37), or (4) HIV- controls without MC (42±8 years, n=41). All participants underwent two-dimensional (2-D), Doppler, and tissue Doppler echocardiography. Overall, the prevalence of systolic dysfunction (15 vs. 4%, p=0.02) and LV hypertrophy (9 vs. 1%, p=0.03) was greater in HIV+ than in HIV- participants. Participants with MC had a greater prevalence of LV hypertrophy (10% vs. 1%). Early mitral annular velocity during diastole was significantly (p<0.005) lower in groups with MC (HIV+/MC+: 11.6±2.3, HIV-/MC+: 12.0±2.3 vs. HIV+/MC -: 12.4±2.3, HIV-/MC-: 13.1±2.4 cm/s) and tended to be lower in groups with HIV (p=0.10). However, there was no interaction effect of HIV and MC for any systolic or diastolic variable. Regardless of HIV status, participants with MC had reduced LV diastolic function. Although both the presence of MC and HIV infection were associated with lower diastolic function, there was no additive negative effect of HIV on diastolic function beyond the effect of MC. Also, HIV was independently associated with lower systolic function. Clinical monitoring of LV function in individuals with metabolic risk factors, regardless of HIV status, is warranted.

AB - Our objective was to determine if the presence of metabolic complications (MC) conveyed an additional risk for left ventricular (LV) dysfunction in people with HIV. HIV+ and HIV- men and women were categorized into four groups: (1) HIV+ with MC (43±7 years, n=64), (2) HIV+ without MC (42±7 years, n=59), (3) HIV- with MC (44±8 years, n=37), or (4) HIV- controls without MC (42±8 years, n=41). All participants underwent two-dimensional (2-D), Doppler, and tissue Doppler echocardiography. Overall, the prevalence of systolic dysfunction (15 vs. 4%, p=0.02) and LV hypertrophy (9 vs. 1%, p=0.03) was greater in HIV+ than in HIV- participants. Participants with MC had a greater prevalence of LV hypertrophy (10% vs. 1%). Early mitral annular velocity during diastole was significantly (p<0.005) lower in groups with MC (HIV+/MC+: 11.6±2.3, HIV-/MC+: 12.0±2.3 vs. HIV+/MC -: 12.4±2.3, HIV-/MC-: 13.1±2.4 cm/s) and tended to be lower in groups with HIV (p=0.10). However, there was no interaction effect of HIV and MC for any systolic or diastolic variable. Regardless of HIV status, participants with MC had reduced LV diastolic function. Although both the presence of MC and HIV infection were associated with lower diastolic function, there was no additive negative effect of HIV on diastolic function beyond the effect of MC. Also, HIV was independently associated with lower systolic function. Clinical monitoring of LV function in individuals with metabolic risk factors, regardless of HIV status, is warranted.

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