Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis

Richard D. Sanders, Daniel Schuepbach, Gerald Goldstein, Gletchen L. Haas, John A. Sweeney, Matcheri S. Keshavan

Research output: Contribution to journalArticle

24 Scopus citations


The authors explored relationships between neuropsychological performance and neurological exam abnormalities in 86 never-medicated patients with nonorganic psychosis (59 with schizophrenia or schizoaffective disorder) and 51 healthy subjects. Assessments include a reliable subset of the Neurological Evaluation Scale (rNES) and several neuropsychological tests of attention, executive function, memory, and current and premorbid intelligence. Principal components analysis of the rNES yielded two main factors. Of these, CogPer (consisting of more cognitively demanding perceptual tasks) showed stronger relationships than RepMot (consisting of repetitive manual motor tasks) to neuropsychological measures. Customarily, frontal neuropsychological tasks also relate more strongly to CogPer than to RepMot. Approximately one-half of the variability in these cognitive and neurological assessments is shared.

Original languageEnglish (US)
Pages (from-to)480-487
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Jan 1 2004


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Sanders, R. D., Schuepbach, D., Goldstein, G., Haas, G. L., Sweeney, J. A., & Keshavan, M. S. (2004). Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis. Journal of Neuropsychiatry and Clinical Neurosciences, 16(4), 480-487.