Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: The NHLBI-sponsored Women's Ischemia Syndrome Evaluation Study

Asma Khaliq, B. Delia Johnson, R. David Anderson, Anthony A. Bavry, Rhonda M. Cooper-DeHoff, Eileen M. Handberg, C. Noel Bairey Merz, Stephen J. Nicholls, Steven Nissen, Carl J. Pepine

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Objective In women, metabolic syndrome (MetS) is associated with higher risk of ischemic heart disease-related adverse outcomes versus individual components. We examined the relationship of MetS to subclinical coronary atherosclerosis. Methods Women (n=100) undergoing coronary angiography for suspected ischemia but without obstructive coronary artery disease (CAD) underwent intravascular ultrasound (IVUS) of a segment of the left coronary artery. A core lab, masked to other findings, assessed IVUS measures and normalized volume measures to pull-back length. MetS [defined using ATPIII criteria (fasting glucose ≥100 mg/dl per revised NCEP guideline)] and its components were entered into multiple regression models to assess associations with IVUS measures. Results Detailed IVUS measurements were available in 87 women. Mean age was 54±10 years, 36% had MetS, and 78% had atheroma. Comparing women with MetS versus without MetS, significant differences were observed for seven IVUS atherosclerosis measures, but were not significant after adjusting for the MetS components. Systolic blood pressure and waist circumference components remained independently positively associated with the IVUS measures after adjusting for age, diabetes, CAD family history, dyslipidemia, smoking, and hormone replacement. Conclusion In women with signs and symptoms of ischemia and no obstructive CAD, MetS is associated with coronary atherosclerosis presence and severity. However, these associations appear largely driven by components of waist circumference and systolic blood pressure versus MetS cluster. This supports the concept that MetS is a convenient clustering of risk factors rather than an independent risk predictor, and emphasizes that the critical factors for coronary atherosclerosis are potentially modifiable.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalCardiovascular Endocrinology
Volume4
Issue number2
DOIs
StatePublished - May 26 2015
Externally publishedYes

Keywords

  • adverse outcomes
  • coronary angiography
  • coronary artery disease
  • coronary atherosclerosis
  • intravascular ultrasound
  • ischemic heart disease
  • metabolic syndrome
  • risk assessment
  • women

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Relationships between components of metabolic syndrome and coronary intravascular ultrasound atherosclerosis measures in women without obstructive coronary artery disease: The NHLBI-sponsored Women's Ischemia Syndrome Evaluation Study'. Together they form a unique fingerprint.

  • Cite this