Relationships between medication treatments and neuropsychological test performance in schizophrenia

John A. Sweeney, John G. Keilp, Gretchen L. Haas, James Hill, Peter J. Weiden

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and benztropine. Neuroleptic dose was correlated with poorer performance on tests of psychomotor speed and attention, and with the number of perseverative errors on the Wisconsin Card Sort. Anticholinergic dose was associated with poorer verbal learning, verbal fluency, and motor speed. Both medication dosages were associated with poorer verbal recognition memory, but this association was strongly influenced by the performance of individuals on the highest medication doses. The findings, which were independent of clinical state and intelligence, indicate that higher doses of neuroleptic and anticholinergic medications are associated with poorer neuropsychological functioning in schizophrenia.

Original languageEnglish (US)
Pages (from-to)297-308
Number of pages12
JournalPsychiatry Research
Volume37
Issue number3
DOIs
StatePublished - 1991

Fingerprint

Neuropsychological Tests
Antipsychotic Agents
Schizophrenia
Cholinergic Antagonists
Benztropine
Verbal Learning
Intelligence
Inpatients
Therapeutics

Keywords

  • anticholinergic medications
  • antipsychotic medications
  • Neuropsychology
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Relationships between medication treatments and neuropsychological test performance in schizophrenia. / Sweeney, John A.; Keilp, John G.; Haas, Gretchen L.; Hill, James; Weiden, Peter J.

In: Psychiatry Research, Vol. 37, No. 3, 1991, p. 297-308.

Research output: Contribution to journalArticle

Sweeney, John A. ; Keilp, John G. ; Haas, Gretchen L. ; Hill, James ; Weiden, Peter J. / Relationships between medication treatments and neuropsychological test performance in schizophrenia. In: Psychiatry Research. 1991 ; Vol. 37, No. 3. pp. 297-308.
@article{beaad029ae604bb3abe2e889c89261a5,
title = "Relationships between medication treatments and neuropsychological test performance in schizophrenia",
abstract = "Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and benztropine. Neuroleptic dose was correlated with poorer performance on tests of psychomotor speed and attention, and with the number of perseverative errors on the Wisconsin Card Sort. Anticholinergic dose was associated with poorer verbal learning, verbal fluency, and motor speed. Both medication dosages were associated with poorer verbal recognition memory, but this association was strongly influenced by the performance of individuals on the highest medication doses. The findings, which were independent of clinical state and intelligence, indicate that higher doses of neuroleptic and anticholinergic medications are associated with poorer neuropsychological functioning in schizophrenia.",
keywords = "anticholinergic medications, antipsychotic medications, Neuropsychology, schizophrenia",
author = "Sweeney, {John A.} and Keilp, {John G.} and Haas, {Gretchen L.} and James Hill and Weiden, {Peter J.}",
year = "1991",
doi = "10.1016/0165-1781(91)90065-W",
language = "English (US)",
volume = "37",
pages = "297--308",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Relationships between medication treatments and neuropsychological test performance in schizophrenia

AU - Sweeney, John A.

AU - Keilp, John G.

AU - Haas, Gretchen L.

AU - Hill, James

AU - Weiden, Peter J.

PY - 1991

Y1 - 1991

N2 - Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and benztropine. Neuroleptic dose was correlated with poorer performance on tests of psychomotor speed and attention, and with the number of perseverative errors on the Wisconsin Card Sort. Anticholinergic dose was associated with poorer verbal learning, verbal fluency, and motor speed. Both medication dosages were associated with poorer verbal recognition memory, but this association was strongly influenced by the performance of individuals on the highest medication doses. The findings, which were independent of clinical state and intelligence, indicate that higher doses of neuroleptic and anticholinergic medications are associated with poorer neuropsychological functioning in schizophrenia.

AB - Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and benztropine. Neuroleptic dose was correlated with poorer performance on tests of psychomotor speed and attention, and with the number of perseverative errors on the Wisconsin Card Sort. Anticholinergic dose was associated with poorer verbal learning, verbal fluency, and motor speed. Both medication dosages were associated with poorer verbal recognition memory, but this association was strongly influenced by the performance of individuals on the highest medication doses. The findings, which were independent of clinical state and intelligence, indicate that higher doses of neuroleptic and anticholinergic medications are associated with poorer neuropsychological functioning in schizophrenia.

KW - anticholinergic medications

KW - antipsychotic medications

KW - Neuropsychology

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0025914326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025914326&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(91)90065-W

DO - 10.1016/0165-1781(91)90065-W

M3 - Article

C2 - 1679950

AN - SCOPUS:0025914326

VL - 37

SP - 297

EP - 308

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -