Relative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension. ICARUS, a LIFE sub study

Michael H. Olsen, Eigil Fossum, Elsa Hjerkinn, Kristian Wachtell, Aud Høieggen, Shawna D. Nesbitt, Ulrik B. Andersen, Robert A. Phillips, Cynthia L. Gaboury, Hans Ibsen, Sverre E. Kjeldsen, Stevo Julius

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Abstract

Background. Insulin resistance is associated with hypertension. The relative influences of hyperinsulinaemia and high blood pressure on vascular hypertrophy and carotid distensibility is unclear in patients with longstanding hypertension. Methods. In 88 unmedicated patients with stage II-III hypertension and left ventricular hypertrophy on electrocardiogram we measured blood pressure, minimal forearm vascular resistance (MFVR) using plethysmography, intima-media thickness (IMT) and the wall distensibility of the common carotid arteries using ultrasound, and insulin sensitivity using a 2-h isoglycaemic hyperinsulinaemic clamp. Results. IMT was positively correlated to systolic blood pressure (r = 0.26, P < 0.05), whole body glucose uptake index (M/IG; r = 0.22, P < 0.05), age (r = 0.24, P < 0.05) and negatively correlated to body mass index (r = -0.24, P < 0.05); IMT did not correlate to fasting serum insulin (r = -0.14, NS). In men (n = 64) MFVR was positively correlated to systolic blood pressure (r = 0.30, P < 0.05), but was unrelated to M/G and serum insulin. The distensibility of the common carotid arteries was negatively correlated to systolic blood pressure (r = -0.40, P < 0.001) and in untreated patients (n = 22) positively correlated to M/IG (r = 0.47, P < 0.05). Conclusions. High systolic blood pressure was related to vascular hypertrophy, whereas hyperinsulinaemia and insulin resistance were not, suggesting that longstanding high blood pressure is a far more important determinant for structural vascular changes than insulin resistance at this stage of the hypertensive disease. However, hyperinsulinaemia and insulin resistance were associated with low distensibility of the common carotid arteries in the subgroup of never treated hypertensive patients. (C) Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalJournal of Hypertension
Volume18
Issue number1
StatePublished - 2000

Fingerprint

Blood Vessels
Insulin Resistance
Blood Pressure
Hypertension
Common Carotid Artery
Hyperinsulinism
Forearm
Vascular Resistance
Hypertrophy
Insulin
Plethysmography
Left Ventricular Hypertrophy
Serum
Fasting
Electrocardiography
Body Mass Index
Glucose

Keywords

  • Hypertension
  • Insulin resistance
  • Intima-media thickness
  • Minimal forearm vascular resistance
  • Vascular hypertrophy
  • Vascular stiffness

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Relative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension. ICARUS, a LIFE sub study. / Olsen, Michael H.; Fossum, Eigil; Hjerkinn, Elsa; Wachtell, Kristian; Høieggen, Aud; Nesbitt, Shawna D.; Andersen, Ulrik B.; Phillips, Robert A.; Gaboury, Cynthia L.; Ibsen, Hans; Kjeldsen, Sverre E.; Julius, Stevo.

In: Journal of Hypertension, Vol. 18, No. 1, 2000, p. 75-81.

Research output: Contribution to journalArticle

Olsen, MH, Fossum, E, Hjerkinn, E, Wachtell, K, Høieggen, A, Nesbitt, SD, Andersen, UB, Phillips, RA, Gaboury, CL, Ibsen, H, Kjeldsen, SE & Julius, S 2000, 'Relative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension. ICARUS, a LIFE sub study', Journal of Hypertension, vol. 18, no. 1, pp. 75-81.
Olsen, Michael H. ; Fossum, Eigil ; Hjerkinn, Elsa ; Wachtell, Kristian ; Høieggen, Aud ; Nesbitt, Shawna D. ; Andersen, Ulrik B. ; Phillips, Robert A. ; Gaboury, Cynthia L. ; Ibsen, Hans ; Kjeldsen, Sverre E. ; Julius, Stevo. / Relative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension. ICARUS, a LIFE sub study. In: Journal of Hypertension. 2000 ; Vol. 18, No. 1. pp. 75-81.
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abstract = "Background. Insulin resistance is associated with hypertension. The relative influences of hyperinsulinaemia and high blood pressure on vascular hypertrophy and carotid distensibility is unclear in patients with longstanding hypertension. Methods. In 88 unmedicated patients with stage II-III hypertension and left ventricular hypertrophy on electrocardiogram we measured blood pressure, minimal forearm vascular resistance (MFVR) using plethysmography, intima-media thickness (IMT) and the wall distensibility of the common carotid arteries using ultrasound, and insulin sensitivity using a 2-h isoglycaemic hyperinsulinaemic clamp. Results. IMT was positively correlated to systolic blood pressure (r = 0.26, P < 0.05), whole body glucose uptake index (M/IG; r = 0.22, P < 0.05), age (r = 0.24, P < 0.05) and negatively correlated to body mass index (r = -0.24, P < 0.05); IMT did not correlate to fasting serum insulin (r = -0.14, NS). In men (n = 64) MFVR was positively correlated to systolic blood pressure (r = 0.30, P < 0.05), but was unrelated to M/G and serum insulin. The distensibility of the common carotid arteries was negatively correlated to systolic blood pressure (r = -0.40, P < 0.001) and in untreated patients (n = 22) positively correlated to M/IG (r = 0.47, P < 0.05). Conclusions. High systolic blood pressure was related to vascular hypertrophy, whereas hyperinsulinaemia and insulin resistance were not, suggesting that longstanding high blood pressure is a far more important determinant for structural vascular changes than insulin resistance at this stage of the hypertensive disease. However, hyperinsulinaemia and insulin resistance were associated with low distensibility of the common carotid arteries in the subgroup of never treated hypertensive patients. (C) Lippincott Williams and Wilkins.",
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T1 - Relative influence of insulin resistance versus blood pressure on vascular changes in longstanding hypertension. ICARUS, a LIFE sub study

AU - Olsen, Michael H.

AU - Fossum, Eigil

AU - Hjerkinn, Elsa

AU - Wachtell, Kristian

AU - Høieggen, Aud

AU - Nesbitt, Shawna D.

AU - Andersen, Ulrik B.

AU - Phillips, Robert A.

AU - Gaboury, Cynthia L.

AU - Ibsen, Hans

AU - Kjeldsen, Sverre E.

AU - Julius, Stevo

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Y1 - 2000

N2 - Background. Insulin resistance is associated with hypertension. The relative influences of hyperinsulinaemia and high blood pressure on vascular hypertrophy and carotid distensibility is unclear in patients with longstanding hypertension. Methods. In 88 unmedicated patients with stage II-III hypertension and left ventricular hypertrophy on electrocardiogram we measured blood pressure, minimal forearm vascular resistance (MFVR) using plethysmography, intima-media thickness (IMT) and the wall distensibility of the common carotid arteries using ultrasound, and insulin sensitivity using a 2-h isoglycaemic hyperinsulinaemic clamp. Results. IMT was positively correlated to systolic blood pressure (r = 0.26, P < 0.05), whole body glucose uptake index (M/IG; r = 0.22, P < 0.05), age (r = 0.24, P < 0.05) and negatively correlated to body mass index (r = -0.24, P < 0.05); IMT did not correlate to fasting serum insulin (r = -0.14, NS). In men (n = 64) MFVR was positively correlated to systolic blood pressure (r = 0.30, P < 0.05), but was unrelated to M/G and serum insulin. The distensibility of the common carotid arteries was negatively correlated to systolic blood pressure (r = -0.40, P < 0.001) and in untreated patients (n = 22) positively correlated to M/IG (r = 0.47, P < 0.05). Conclusions. High systolic blood pressure was related to vascular hypertrophy, whereas hyperinsulinaemia and insulin resistance were not, suggesting that longstanding high blood pressure is a far more important determinant for structural vascular changes than insulin resistance at this stage of the hypertensive disease. However, hyperinsulinaemia and insulin resistance were associated with low distensibility of the common carotid arteries in the subgroup of never treated hypertensive patients. (C) Lippincott Williams and Wilkins.

AB - Background. Insulin resistance is associated with hypertension. The relative influences of hyperinsulinaemia and high blood pressure on vascular hypertrophy and carotid distensibility is unclear in patients with longstanding hypertension. Methods. In 88 unmedicated patients with stage II-III hypertension and left ventricular hypertrophy on electrocardiogram we measured blood pressure, minimal forearm vascular resistance (MFVR) using plethysmography, intima-media thickness (IMT) and the wall distensibility of the common carotid arteries using ultrasound, and insulin sensitivity using a 2-h isoglycaemic hyperinsulinaemic clamp. Results. IMT was positively correlated to systolic blood pressure (r = 0.26, P < 0.05), whole body glucose uptake index (M/IG; r = 0.22, P < 0.05), age (r = 0.24, P < 0.05) and negatively correlated to body mass index (r = -0.24, P < 0.05); IMT did not correlate to fasting serum insulin (r = -0.14, NS). In men (n = 64) MFVR was positively correlated to systolic blood pressure (r = 0.30, P < 0.05), but was unrelated to M/G and serum insulin. The distensibility of the common carotid arteries was negatively correlated to systolic blood pressure (r = -0.40, P < 0.001) and in untreated patients (n = 22) positively correlated to M/IG (r = 0.47, P < 0.05). Conclusions. High systolic blood pressure was related to vascular hypertrophy, whereas hyperinsulinaemia and insulin resistance were not, suggesting that longstanding high blood pressure is a far more important determinant for structural vascular changes than insulin resistance at this stage of the hypertensive disease. However, hyperinsulinaemia and insulin resistance were associated with low distensibility of the common carotid arteries in the subgroup of never treated hypertensive patients. (C) Lippincott Williams and Wilkins.

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