Relaxation effects in the quantification of fat using gradient echo imaging

Mark Bydder, Takeshi Yokoo, Gavin Hamilton, Michael S. Middleton, Alyssa D. Chavez, Jeffrey B. Schwimmer, Joel E. Lavine, Claude B. Sirlin

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

Quantification of fat has been investigated using images acquired from multiple gradient echos. The evolution of the signal with echo time and flip angle was measured in phantoms of known fat and water composition and in 21 research subjects with fatty liver. Data were compared to different models of the signal equation, in which each model makes different assumptions about the T1 and/or T2* relaxation effects. A range of T1, T2*, fat fraction and number of echos was investigated to cover situations of relevance to clinical imaging. Results indicate that quantification is most accurate at low flip angles (to minimize T1 effects) with a small number of echos (to minimize spectral broadening effects). At short echo times, the spectral broadening effects manifest as a short apparent T2 for the fat component.

Original languageEnglish (US)
Pages (from-to)347-359
Number of pages13
JournalMagnetic Resonance Imaging
Volume26
Issue number3
DOIs
StatePublished - Apr 2008

Fingerprint

fats
Oils and fats
echoes
Fats
Imaging techniques
gradients
Research Subjects
Medical imaging
Fatty Liver
Liver
liver
Water
Chemical analysis
water

Keywords

  • Dixon
  • Fat quantification
  • T1 relaxation
  • T2* relaxation

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Bydder, M., Yokoo, T., Hamilton, G., Middleton, M. S., Chavez, A. D., Schwimmer, J. B., ... Sirlin, C. B. (2008). Relaxation effects in the quantification of fat using gradient echo imaging. Magnetic Resonance Imaging, 26(3), 347-359. https://doi.org/10.1016/j.mri.2007.08.012

Relaxation effects in the quantification of fat using gradient echo imaging. / Bydder, Mark; Yokoo, Takeshi; Hamilton, Gavin; Middleton, Michael S.; Chavez, Alyssa D.; Schwimmer, Jeffrey B.; Lavine, Joel E.; Sirlin, Claude B.

In: Magnetic Resonance Imaging, Vol. 26, No. 3, 04.2008, p. 347-359.

Research output: Contribution to journalArticle

Bydder, M, Yokoo, T, Hamilton, G, Middleton, MS, Chavez, AD, Schwimmer, JB, Lavine, JE & Sirlin, CB 2008, 'Relaxation effects in the quantification of fat using gradient echo imaging', Magnetic Resonance Imaging, vol. 26, no. 3, pp. 347-359. https://doi.org/10.1016/j.mri.2007.08.012
Bydder, Mark ; Yokoo, Takeshi ; Hamilton, Gavin ; Middleton, Michael S. ; Chavez, Alyssa D. ; Schwimmer, Jeffrey B. ; Lavine, Joel E. ; Sirlin, Claude B. / Relaxation effects in the quantification of fat using gradient echo imaging. In: Magnetic Resonance Imaging. 2008 ; Vol. 26, No. 3. pp. 347-359.
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