Release of TSH by TRF infused directly into a pituitary stalk portal vessel

J. C. Porter, W. Vale, R. Burgus, R. S. Mical, R. Guillemin

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Abstract

Synthetic TRF (pyroglutamylhistidyl-proline amide) was infused (1 ng/min) for 20 min (1) into the anterior pituitary of 10 rats by way of a cannulated hypophysial stalk portal vessel or (2) into a femoral vein of 10 rats. At the end of the 20-min infusion period, the plasma concentration of TSH in 8 of 10 rats given TRF via a cannulated portal vessel was significantly greater than the pre-infusion level. In contrast, in only 3 of 10 rats given TRF via a femoral vein was the plasma concentration of TSH significantly greater than the pre-infusion level of TSH.

Original languageEnglish (US)
Pages (from-to)1054-1056
Number of pages3
JournalEndocrinology
Volume89
Issue number4
DOIs
StatePublished - Oct 1971

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ASJC Scopus subject areas

  • Endocrinology

Cite this

Porter, J. C., Vale, W., Burgus, R., Mical, R. S., & Guillemin, R. (1971). Release of TSH by TRF infused directly into a pituitary stalk portal vessel. Endocrinology, 89(4), 1054-1056. https://doi.org/10.1210/endo-89-4-1054