Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors

Daniel M. Green, Larry E. Kun, Katherine K. Matthay, Anna T. Meadows, William H. Meyer, Paul A. Meyers, Sheri L. Spunt, Leslie L. Robison, Melissa M. Hudson

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse-free survival and reduce long-term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects.

Original languageEnglish (US)
Pages (from-to)1083-1094
Number of pages12
JournalPediatric Blood and Cancer
Volume60
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Childhood cancer therapy
  • Late effects
  • Long-term follow-up

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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  • Cite this

    Green, D. M., Kun, L. E., Matthay, K. K., Meadows, A. T., Meyer, W. H., Meyers, P. A., Spunt, S. L., Robison, L. L., & Hudson, M. M. (2013). Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors. Pediatric Blood and Cancer, 60(7), 1083-1094. https://doi.org/10.1002/pbc.24487