TY - JOUR
T1 - Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women
AU - Ali, M. Aktar
AU - Akhmedkhanov, Arslan
AU - Zeleniuch-Jaquotte, Anne
AU - Toniolo, Paolo
AU - Frenkel, Krystyna
AU - Huang, Xi
N1 - Funding Information:
This study was supported by a grant from the Department of Defense (DAMD17-01-10576) and in part by grants CA34588 and CA16087 from the National Cancer Institute.
PY - 2003
Y1 - 2003
N2 - Reliability of serum levels of iron, ferritin and nitrite (NO2-) over a 2-year period were evaluated in 40 healthy women (20 pre-menopausal and 20 post-menopausal), ages 39-65 years, from the New York University Women's Health Study (NYUWHS). Three blood samples per woman collected at yearly intervals were analyzed. Reliability coefficients (RCs) of serum iron, ferritin, and nitrite were 0.03 (95% confidence interval (CI), 0-0.33), 0.90 (95% CI, 0.79-0.95), and 0.72 (95% CI, 0.50-0.86), respectively, for pre-menopausal women, and 0.26 (95% CI, 0-0.56), 0.77 (95% CI, 0.59-0.89), and 0.55 (95% CI, 0.30-0.77), respectively, for post-menopausal women. In a case-control study nested within NYUWHS cohort, serum levels of nitrite, ferritin, and iron were measured in women apparently healthy at the time of blood donation but diagnosed with renal cancer 1.8-12.2 years later (n = 24) and in individually matched controls (two per case). The results suggest that high serum levels of ferritin and nitrite may be associated with a decreased risk of renal cancer (odds ratio (OR), 0.55, 95% CI, 0.15-2.01 for ferritin, and OR, 0.52, 95% CI, 0.17-1.60 for nitrite in women with above median level as compared to women with below median level). The possible role of ferritin and nitrite in renal cancer is discussed.
AB - Reliability of serum levels of iron, ferritin and nitrite (NO2-) over a 2-year period were evaluated in 40 healthy women (20 pre-menopausal and 20 post-menopausal), ages 39-65 years, from the New York University Women's Health Study (NYUWHS). Three blood samples per woman collected at yearly intervals were analyzed. Reliability coefficients (RCs) of serum iron, ferritin, and nitrite were 0.03 (95% confidence interval (CI), 0-0.33), 0.90 (95% CI, 0.79-0.95), and 0.72 (95% CI, 0.50-0.86), respectively, for pre-menopausal women, and 0.26 (95% CI, 0-0.56), 0.77 (95% CI, 0.59-0.89), and 0.55 (95% CI, 0.30-0.77), respectively, for post-menopausal women. In a case-control study nested within NYUWHS cohort, serum levels of nitrite, ferritin, and iron were measured in women apparently healthy at the time of blood donation but diagnosed with renal cancer 1.8-12.2 years later (n = 24) and in individually matched controls (two per case). The results suggest that high serum levels of ferritin and nitrite may be associated with a decreased risk of renal cancer (odds ratio (OR), 0.55, 95% CI, 0.15-2.01 for ferritin, and OR, 0.52, 95% CI, 0.17-1.60 for nitrite in women with above median level as compared to women with below median level). The possible role of ferritin and nitrite in renal cancer is discussed.
KW - Ferritin
KW - Nitrite
KW - Reliability
KW - Renal cancer
KW - Serum iron
UR - http://www.scopus.com/inward/record.url?scp=0037260842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037260842&partnerID=8YFLogxK
U2 - 10.1016/S0361-090X(03)00027-8
DO - 10.1016/S0361-090X(03)00027-8
M3 - Article
C2 - 12670522
AN - SCOPUS:0037260842
SN - 0361-090X
VL - 27
SP - 116
EP - 121
JO - Cancer detection and prevention
JF - Cancer detection and prevention
IS - 2
ER -