Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.

Original languageEnglish (US)
JournalPLoS Pathogens
Volume3
Issue number8
DOIs
StatePublished - Aug 31 2007

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Metabolic Networks and Pathways
Life Cycle Stages
Hepacivirus
Cholesterol
Flaviviridae
RNA Viruses
Liver Failure
Virus Diseases
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. / Ye, Jin.

In: PLoS Pathogens, Vol. 3, No. 8, 31.08.2007.

Research output: Contribution to journalArticle

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