Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

Hepatitis C virus (HCV), a single-stranded positivesense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.

Original languageEnglish (US)
Pages (from-to)1017-1022
Number of pages6
JournalPLoS pathogens
Volume3
Issue number8
DOIs
StatePublished - Aug 1 2007

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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