Remission induction, consolidation and novel agents in development for adults with acute myeloid leukaemia

Mehdi Hamadani, Farrukh T. Awan

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Chemotherapy regimens used for remission induction in AML have not changed significantly over the last several decades. However the recognition of the prognostic value of cytogenetics and genomics has been a major advance which is helping clarify the most optimal post-remission consolidation strategy among various risk groups. We are not only beginning to realize the pitfalls of a 'one-fits-all' approach with intensive, cytarabine-based chemotherapy as the mainstay, but we are finally beginning to reap the rewards of decades of basic, translational, and clinical research. Developing individualized, 'targeted' therapy for each AML patient based on unique molecular features of disease remains a daunting goal yet one that we can now begin to envision. Hypothesis-based study designs-from preclinical/ laboratory experiments to phase-I and subsequent efficacy trials - provide the foundation for advances in the diagnosis, risk stratification, and treatment for patients with AML. Here we critically review the literature for the management of AML, try to give recommendations regarding the appropriate induction and remission strategy, clarify the role of stem cell transplantation and discuss novel agents on the horizon.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalHematological Oncology
Volume28
Issue number1
DOIs
StatePublished - Mar 1 2010

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Keywords

  • Acute myeloid leukaemia
  • Cytarabine
  • Daunorubicin
  • HIDAC
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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