Renal angiomyolipomas and HMB-45 reactivity

R. Ashfaq, A. G. Weinberg, J. Albores-Saavedra

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Background. Renal angiomyolipomas (RAML) are mesenchymal hamartomas composed of varying amounts of blood vessels, smooth muscle, adipose tissue, and supporting connective tissue. Although most of these tumors are easy to recognize, some show unusual histologic features and may pose a diagnostic dilemma. Recent reports indicate that RAML are immunoreactive for HMB-45 antibody, which is directed against a premelanomasome-associated glycoprotein and is thought to be specific for melanocytic differentiation. Methods. To determine whether HMB-45 reactivity would differentiate RAML from other renal tumors, the authors immunostained 72 primary renal tumors, including 19 angiomyolipomas and 2 retroperitoneal liposarcomas extending into the kidney, with HMB-45 monoclonal antibody. Also, the immunohistochemical profile of 19 renal angiomyolipomas was investigated using a broad panel of immunostains, including cytokeratin (AE1/AE3), epithelial membrane antigen, vimentin, smooth muscle actin (SMA), desmin, muscle-specific actin (MSA), S-100 protein, and neuron-specific enolase (NSE). Results. All tumors except RAML were negative for HMB-45 antibody. HMB-45 immunoreactivity was present in 17 of 19 RAML. Seventeen of 19 were positive for SMA and MSA (HHF 35), 8 for desmin, 17 for vimentin, and 9 for NSE. Conclusions. Based on this study, it was concluded that, along with SMA and MSA, HMB-45 reactivity is a useful tool to distinguish RAML, especially those with unusual morphologic features, from other primary renal neoplasms, including liposarcomas that extend into the kidney.

Original languageEnglish (US)
Pages (from-to)3091-3097
Number of pages7
JournalCancer
Volume71
Issue number10
StatePublished - 1993

Fingerprint

Angiomyolipoma
Kidney
Actins
Smooth Muscle
Muscles
Desmin
Phosphopyruvate Hydratase
Vimentin
Neoplasms
Liposarcoma
Mucin-1
Hamartoma
S100 Proteins
Antibodies
Kidney Neoplasms
Keratins
Connective Tissue
Blood Vessels
Adipose Tissue
Glycoproteins

Keywords

  • angiomyolipoma
  • cross reactivity
  • HMB-45
  • shared epitopes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ashfaq, R., Weinberg, A. G., & Albores-Saavedra, J. (1993). Renal angiomyolipomas and HMB-45 reactivity. Cancer, 71(10), 3091-3097.

Renal angiomyolipomas and HMB-45 reactivity. / Ashfaq, R.; Weinberg, A. G.; Albores-Saavedra, J.

In: Cancer, Vol. 71, No. 10, 1993, p. 3091-3097.

Research output: Contribution to journalArticle

Ashfaq, R, Weinberg, AG & Albores-Saavedra, J 1993, 'Renal angiomyolipomas and HMB-45 reactivity', Cancer, vol. 71, no. 10, pp. 3091-3097.
Ashfaq R, Weinberg AG, Albores-Saavedra J. Renal angiomyolipomas and HMB-45 reactivity. Cancer. 1993;71(10):3091-3097.
Ashfaq, R. ; Weinberg, A. G. ; Albores-Saavedra, J. / Renal angiomyolipomas and HMB-45 reactivity. In: Cancer. 1993 ; Vol. 71, No. 10. pp. 3091-3097.
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