Renal-Limited "lupus-Like" Nephritis: How Much of a Lupus

Asmaa S.Abu Maziad, Jose Torrealba, Mouin G. Seikaly, Jared R. Hassler, Allen R. Hendricks

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus nephritis with no clinical signs or symptoms of SLE and negative autoantibodies. He was treated with corticosteroids, mycophenolate mofetil, and monthly intravenous cyclophosphamide. During the 2-year follow-up period, the proteinuria resolved and kidney function improved with continued negative autoantibody workup. This case presents a category of renal-limited "lupus-like" glomerulonephritis which can be challenging to treat and carries a poor prognosis.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalCase Reports in Nephrology and Dialysis
Volume7
Issue number2
DOIs
StatePublished - May 2 2017

Keywords

  • Antinuclear antibodies
  • Full-house
  • Lupus-like nephritis

ASJC Scopus subject areas

  • Nephrology

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