Renal metanephric adenoma with previously unreported cytogenetic abnormalities: Case report and review of the literature

Dinesh Rakheja, Fangru Lian, Gail E. Tomlinson, David H. Ewalt, Roger A. Schultz, Linda R. Margraf

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We report a case of a renal metanephric adenoma in a 10-year-old boy, in which cytogenetic analysis showed a balanced translocation, t(9;15)(p24;q24) and a balanced paracentric inversion of chromosome 12, inv(12)(q13q15). Immunohistochemically, the tumor showed diffuse reactivity for cytokeratin AE1/AE3, CAM5.2, CD57, and WT1; patchy reactivity for CD56; and focal reactivity for cytokeratin 7, epithelial membrane antigen, and CD10. Tumor cells were entirely nonreactive for α-methyl acyl coenzyme A racemase. Published cytogenetic data for metanephric adenomas are limited, and this is the first report of these cytogenetic abnormalities. The involvement of the chromosome region 9p24 is particularly interesting because of the recent identification of a tumor suppressor gene, KANK (kidney ankyrin repeat-containing protein), at this locus.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalPediatric and Developmental Pathology
Volume8
Issue number2
DOIs
StatePublished - Apr 1 2005

Keywords

  • Cytogenetics
  • Metanephric adenoma
  • Papillary renal cell carcinoma
  • Wilms tumor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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